{"id":"W4405126133","doi":"10.1182/blood-2024-205641","title":"A CD33-Deleted Allograft (Trem-cel) Enables Post-Hematopoietic Cell Transplant (HCT) Maintenance Dosing of Gemtuzumab Ozogamicin (GO) with Therapeutic Levels of Drug Exposure and Low Hematologic and Hepatic Toxicity in Patients with High-Risk Acute Myeloid Leukemia (AML)","year":2024,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"","keywords":"Gemtuzumab ozogamicin; Calicheamicin; Dosing; Medicine; Toxicity; CD33; Pharmacology; Hematopoietic cell; Hematopoietic stem cell transplantation; Drug; Haematopoiesis; Internal medicine; Transplantation; Stem cell; Myeloid leukemia; Biology; CD34","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000199877,0.0002141079,0.0002161171,0.0001420873,0.0001087916,0.0002528917,0.0002178749,0.0002644596,0.002576791],"category_scores_gemma":[0.0001100875,0.00008662164,0.0001989081,0.00009273223,0.0001680681,0.0002008281,0.0001781462,0.0006991532,0.0005358763],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002080147,"about_ca_system_score_gemma":0.0002994264,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002247159,"about_ca_topic_score_gemma":0.000364499,"domain_scores_codex":[0.9999278,0.0000112633,0.000004251421,0.00001561415,0.00001880436,0.00002221823],"domain_scores_gemma":[0.9999397,0.00000487421,0.00001843412,0.000006728066,0.000004533046,0.00002572253],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.006509122,0.002566809,0.002771576,0.0002293489,0.00007257455,0.0005154264,0.00007457089,0.001154876,0.9262797,0.001041347,0.0021158,0.05666891],"study_design_scores_gemma":[0.005586795,0.06054192,0.02661159,0.00006427945,0.0004361577,0.006536666,0.00009794177,0.007241718,0.8510823,0.0003575796,0.04140363,0.00003927533],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953251,0.0005833003,0.001805424,0.0001233778,0.0000399031,0.0001376421,0.0004016591,0.000168614,0.001415019],"genre_scores_gemma":[0.9959418,0.0003279905,0.00167015,0.00009921421,0.000009252628,0.0000825852,0.0006302987,0.00001352811,0.001225107],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002576791,"threshold_uncertainty_score":0.008620262,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004708390195735285,"score_gpt":0.1947379178658015,"score_spread":0.1900295276700662,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}