{"id":"W4405126143","doi":"10.1182/blood-2024-200290","title":"High-Risk Subgroups and MRD: An Updated Analysis of the Phase 3 ECHO Trial of Acalabrutinib with Bendamustine/Rituximab in Previously Untreated Mantle Cell Lymphoma","year":2024,"lang":"en","type":"article","venue":"Blood","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Cilag; Pharmacyclics; Swedish Orphan Biovitrum; F. Hoffmann-La Roche; Incyte; BeiGene; Regeneron Pharmaceuticals; Gilead Sciences; MorphoSys; Celgene; AstraZeneca; Eli Lilly and Company; GlaxoSmithKline; Amgen","keywords":"Bendamustine; Mantle cell lymphoma; Medicine; Internal medicine; Rituximab; Oncology; Phases of clinical research; Lymphoma; Clinical trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004117478,0.0005249097,0.001255909,0.0003684547,0.0002173837,0.001059963,0.0005659126,0.0005212884,0.002066436],"category_scores_gemma":[0.002687207,0.0002650303,0.001157684,0.0006995208,0.000216181,0.0006291191,0.0005029097,0.001078106,0.0003022769],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003932452,"about_ca_system_score_gemma":0.0006431583,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00087196,"about_ca_topic_score_gemma":0.002854579,"domain_scores_codex":[0.99874,0.0006924267,0.0001115173,0.0001630181,0.0001903889,0.000102616],"domain_scores_gemma":[0.9981593,0.0005130937,0.0006563794,0.0001779969,0.0001835064,0.0003097366],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.543816,0.003005089,0.2706863,0.001618662,0.0158214,0.0004009203,0.0002913157,0.002665518,0.01481099,0.000425127,0.01192638,0.1345323],"study_design_scores_gemma":[0.1461288,0.03900676,0.7581891,0.0002222058,0.02375981,0.001040782,0.0001692806,0.003220795,0.00385361,0.001011291,0.02328484,0.000112678],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9823582,0.008745865,0.0006504108,0.0005219449,0.00007526284,0.0004847268,0.004343702,0.00004417104,0.00277563],"genre_scores_gemma":[0.9879889,0.001758189,0.000777623,0.000660648,0.0002033216,0.0003669301,0.007488412,0.00002287117,0.000733174],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004117478,"threshold_uncertainty_score":0.02177554,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007631377048258434,"score_gpt":0.2546233731632256,"score_spread":0.2469919961149671,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}