{"id":"W4405151349","doi":"10.1101/2024.12.05.24318563","title":"Human Organ Chips Reveal New Inflammatory Bowel Disease Drivers","year":2024,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Lymphatic System and Diseases","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"","keywords":"Inflammatory bowel disease; Inflammation; Fibrosis; Mucus; Disease; Stroma; Medicine; Cystic fibrosis; Immunology; Cancer research; Pathology; Biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004866075,0.0002910802,0.0002804766,0.0003014708,0.0001694576,0.001016243,0.0002306454,0.0005021048,0.003825194],"category_scores_gemma":[0.0004925625,0.0002607417,0.0003492571,0.0002587368,0.0002694288,0.0003254954,0.000673202,0.0005573196,0.001043099],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000209962,"about_ca_system_score_gemma":0.0001628741,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002916966,"about_ca_topic_score_gemma":0.000303867,"domain_scores_codex":[0.9996044,0.00007395199,0.00001685449,0.0001056572,0.0001421419,0.00005698811],"domain_scores_gemma":[0.9997451,0.00007975786,0.0000478187,0.00006119173,0.00003191016,0.00003419244],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003758591,0.00003364146,0.009213217,0.000277337,0.000062692,0.0004535981,0.0001987461,0.0008630421,0.9645885,0.00264322,0.002042362,0.01924778],"study_design_scores_gemma":[0.00005134349,0.0006452738,0.05638945,0.00009026167,0.0001961145,0.003904696,0.0004790994,0.006049344,0.801726,0.002497111,0.127904,0.00006727364],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8983505,0.01194081,0.06684469,0.00114721,0.0003164124,0.00008100763,0.007798649,0.001065267,0.01245529],"genre_scores_gemma":[0.9685174,0.004260502,0.01541447,0.0005149373,0.00005423612,0.00009574609,0.005409263,0.0001580893,0.005575398],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003825194,"threshold_uncertainty_score":0.01279652,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02098587593711779,"score_gpt":0.2803725128284812,"score_spread":0.2593866368913634,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}