{"id":"W4405155927","doi":"10.1002/hbm.70089","title":"Grey‐Matter Structure Markers of Alzheimer's Disease, Alzheimer's Conversion, Functioning and Cognition: A Meta‐Analysis Across 11 Cohorts","year":2025,"lang":"en","type":"review","venue":"Human Brain Mapping","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Health and Medical Research Council; Australian Research Council; National Center for Advancing Translational Sciences; Medical Research Council; Canadian Institutes of Health Research; Horizon 2020 Framework Programme; National Institutes of Health; Université de Genève; U.S. Department of Defense; Ministère de l'Enseignement supérieur, de la Recherche et de l'Innovation; Université de Bordeaux; Ministero della Salute; National Science Foundation; Dementia Collaborative Research Centres, Australia; Fondazione Cariplo; University of Melbourne; Institut National de la Santé et de la Recherche Médicale; Swansea University; European Federation of Pharmaceutical Industries and Associations; Neuroscience Research Australia; Northern California Institute for Research and Education; National Institute on Aging; Commonwealth Scientific and Industrial Research Organisation; National Institute for Health and Care Research; Agence Nationale de la Recherche; University of Southern California; University College London Hospitals NHS Foundation Trust; European Commission; Alzheimer's Disease Neuroimaging Initiative; Fondation Plan Alzheimer; University of Queensland","keywords":"Grey matter; Psychology; Alzheimer's disease; Atrophy; Temporal lobe; Neuroscience; Cognition; Dementia; Voxel-based morphometry; Region of interest; Temporal cortex; White matter; Disease; Internal medicine; Medicine; Magnetic resonance imaging","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0008284457,0.00065667,0.003536433,0.001043149,0.0005445502,0.0001456237,0.0001889445,0.0002699307,0.006372407],"category_scores_gemma":[0.0001124418,0.0005497361,0.002056213,0.001366933,0.0004021114,0.0001622735,0.0003498575,0.0005295736,0.00002077305],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004132886,"about_ca_system_score_gemma":0.0002885496,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004257187,"about_ca_topic_score_gemma":0.00001787074,"domain_scores_codex":[0.9962409,0.0004579908,0.0009853108,0.0009745669,0.0007452007,0.0005960292],"domain_scores_gemma":[0.9975533,0.0004753371,0.0005667807,0.0005746604,0.000463775,0.0003661321],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.0001300079,0.0002041098,0.02478565,0.05489144,0.8636963,0.0003028836,0.000240757,0.000001169128,0.00001525574,0.00006213698,0.01288719,0.0427831],"study_design_scores_gemma":[0.0009207585,0.00009284694,0.05618961,0.007053039,0.7666909,0.00003326631,0.0002901997,0.00000689363,0.000003597497,0.00009084981,0.1680664,0.0005616583],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003494621,0.9951447,0.0002336946,0.0002873851,0.00009366601,0.002129536,0.0004851934,0.00005568794,0.001220726],"genre_scores_gemma":[0.03678841,0.9487,0.0001811359,0.001977037,0.0003308944,0.0006358078,0.006874187,0.0001447385,0.004367793],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.1551792,"threshold_uncertainty_score":0.9996954,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07042069965911009,"score_gpt":0.3696487936275749,"score_spread":0.2992280939684648,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}