{"id":"W4405161825","doi":"10.1021/acsomega.4c06141","title":"An Efficient and Accessible Hectogram-Scale Synthesis for the Selective O-GlcNAcase Inhibitor Thiamet-G","year":2024,"lang":"en","type":"article","venue":"ACS Omega","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Weston Brain Institute","keywords":"Scale (ratio); Environmental science; Physics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003286265,0.0001110157,0.00008539805,0.00006268619,0.0001981713,0.0001971803,0.0001612686,0.0001012456,0.000008316274],"category_scores_gemma":[0.0001649878,0.00007480185,0.00005690748,0.0002018727,0.00008835611,0.000007170992,0.0000744722,0.0001029924,0.000008894472],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001453527,"about_ca_system_score_gemma":0.0000783968,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004214955,"about_ca_topic_score_gemma":0.00007718151,"domain_scores_codex":[0.9991218,0.00005181259,0.0001094328,0.000348392,0.0001387084,0.0002298868],"domain_scores_gemma":[0.9994162,0.000127002,0.00001828274,0.0002635834,0.00009123833,0.0000837302],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003231303,0.0001817178,0.0008092829,0.0001530225,0.0001597832,0.000007837068,0.000325377,0.0003814189,0.8936134,0.0004696644,0.007542183,0.09603316],"study_design_scores_gemma":[0.0002860472,0.0003795597,0.001212302,0.00002625661,0.00003538107,0.00002075471,0.0002239889,0.009932064,0.9005669,0.0001098416,0.08702036,0.000186572],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990992,0.002702002,0.004286612,0.0007561978,0.0001282723,0.0005912081,0.00005223304,0.0000344334,0.0004570366],"genre_scores_gemma":[0.9981686,0.0001278711,0.0004344003,0.0001163934,0.0002696659,0.0002990562,0.00002320686,0.00002380109,0.0005369401],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09584659,"threshold_uncertainty_score":0.3050331,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01317433133676918,"score_gpt":0.3107988002788049,"score_spread":0.2976244689420356,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}