{"id":"W4405175548","doi":"10.1016/j.jpet.2024.100057","title":"TLR4 downregulation protects against cisplatin-induced ototoxicity in adult and pediatric patients with cancer","year":2024,"lang":"en","type":"article","venue":"Journal of Pharmacology and Experimental Therapeutics","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta Hospital; Western University; Princess Margaret Cancer Centre; University Health Network; University of Toronto; BC Children's Hospital; University of Alberta; Sinai Health System","funders":"","keywords":"Ototoxicity; Cisplatin; Downregulation and upregulation; Medicine; Cancer; Pharmacology; Internal medicine; Chemistry; Chemotherapy; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001776767,0.0001720748,0.0003682605,0.0001190911,0.000134746,0.0002123548,0.0001847344,0.0001785353,0.002177428],"category_scores_gemma":[0.00043353,0.0001040695,0.0002380262,0.0001189993,0.000155081,0.0002106405,0.0002472928,0.000534132,0.0001869918],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002449758,"about_ca_system_score_gemma":0.00052493,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005880461,"about_ca_topic_score_gemma":0.0009572209,"domain_scores_codex":[0.9999,0.00002452204,0.000009092898,0.00001746367,0.00001867808,0.00003028822],"domain_scores_gemma":[0.9998115,0.00002914293,0.00006779632,0.0000131537,0.0000253594,0.00005309689],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0478776,0.002300955,0.3009387,0.001062022,0.0007342835,0.002500375,0.0004311717,0.001248588,0.3672966,0.0005891786,0.006548213,0.2684723],"study_design_scores_gemma":[0.002456554,0.03834655,0.8424499,0.00022687,0.001142484,0.008121769,0.001213002,0.002490279,0.08170608,0.0005180404,0.02127538,0.00005319287],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953849,0.002778418,0.0004196437,0.0002067241,0.00003546602,0.00003152885,0.0002234052,0.00003641346,0.0008835704],"genre_scores_gemma":[0.9971614,0.001350139,0.0003918524,0.0001438243,0.00001759807,0.00003572015,0.0003269522,0.0000052001,0.0005673883],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002177428,"threshold_uncertainty_score":0.007284164,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01135803320081713,"score_gpt":0.3040860366452066,"score_spread":0.2927280034443894,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}