{"id":"W4405181202","doi":"10.1158/1538-8514.cancerchem24-a012","title":"Abstract A012: Discovery and characterization of Casdatifan (AB521), a clinical-stage, potent, and selective Hypoxia-Inducible Factor (HIF)-2α inhibitor","year":2024,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Cancer research; Hypoxia-inducible factors; Small molecule; Pharmacology; Angiogenesis; Hypoxia (environmental); Pharmacophore; Drug discovery; Biology; Chemistry; Biochemistry; Gene","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001733865,0.000271765,0.0003228441,0.00008473107,0.00006942414,0.0001167806,0.0001135139,0.0002572194,0.00001218188],"category_scores_gemma":[0.0000159962,0.0002541757,0.0001375403,0.0001852506,0.0001722245,0.00003149625,0.0000970473,0.0002199078,0.000001215062],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002634384,"about_ca_system_score_gemma":0.0002507272,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009206005,"about_ca_topic_score_gemma":0.00005310878,"domain_scores_codex":[0.9984378,0.00007771133,0.0004064946,0.0006146498,0.0001875133,0.0002758408],"domain_scores_gemma":[0.999289,0.0000214584,0.0001483709,0.0003248081,0.0001079133,0.0001084308],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001073721,0.00005555362,0.000961309,0.000141251,0.0003544764,0.000004017344,0.0001637325,0.000005425709,0.9216712,0.00008103329,0.00004643339,0.07640825],"study_design_scores_gemma":[0.0007987308,0.0002390426,0.05365516,0.0001106314,0.0002025725,0.00001080461,0.00005120187,0.0001106015,0.792971,0.00006893863,0.1513793,0.0004019947],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9679552,0.02685368,0.002809071,0.0002097431,0.001220573,0.0003501307,0.000457279,0.00002322433,0.0001210608],"genre_scores_gemma":[0.9762859,0.02141331,0.0001201085,0.0005807709,0.0007895315,0.00003922239,0.0001246928,0.00006529246,0.0005811893],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1513329,"threshold_uncertainty_score":0.9999911,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02797363305221709,"score_gpt":0.3158958127372145,"score_spread":0.2879221796849974,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}