{"id":"W4405181202","doi":"10.1158/1538-8514.cancerchem24-a012","title":"Abstract A012: Discovery and characterization of Casdatifan (AB521), a clinical-stage, potent, and selective Hypoxia-Inducible Factor (HIF)-2α inhibitor","year":2024,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Cancer research; Hypoxia-inducible factors; Small molecule; Pharmacology; Angiogenesis; Hypoxia (environmental); Pharmacophore; Drug discovery; Biology; Chemistry; Biochemistry; Gene","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002042205,0.0004747642,0.0001744164,0.0002333249,0.0001317712,0.0003078866,0.0003434971,0.0003454018,0.001903231],"category_scores_gemma":[0.0001252055,0.00009617814,0.0001857043,0.0001738298,0.0001209196,0.0001956848,0.0001319963,0.000397165,0.00083787],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004927954,"about_ca_system_score_gemma":0.0005975193,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001252842,"about_ca_topic_score_gemma":0.001606884,"domain_scores_codex":[0.9999206,0.000008988168,0.000005363273,0.00001745414,0.00003203539,0.00001545897],"domain_scores_gemma":[0.999958,0.00000272313,0.00001006366,0.000003372805,0.00001179126,0.00001401644],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003836376,0.0002205435,0.0003856419,0.0002427594,0.00001873138,0.000169438,0.00001796605,0.001412057,0.962644,0.00137174,0.002613466,0.03052007],"study_design_scores_gemma":[0.0001784398,0.001702984,0.001377752,0.00002789072,0.00002923486,0.0006504952,0.00001304482,0.004833344,0.9594633,0.0001793713,0.0315207,0.00002340234],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8846532,0.01699101,0.05376825,0.001969287,0.0004087704,0.001455644,0.008166207,0.0007513321,0.03183632],"genre_scores_gemma":[0.9517593,0.004712893,0.0208854,0.0004207632,0.00004477854,0.0002314982,0.005270313,0.00004547958,0.01662954],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001903231,"threshold_uncertainty_score":0.006366968,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02797363305221709,"score_gpt":0.3158958127372145,"score_spread":0.2879221796849974,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}