{"id":"W4405181441","doi":"10.1158/1538-8514.cancerchem24-ia017","title":"Abstract IA017: Transferrin receptor targeting chimeras (TransTACs) for targeted degradation of membrane and extracellular proteins in cancer","year":2024,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Transferrin receptor; Epidermal growth factor receptor; Cancer cell; Cancer; Cancer research; Targeted therapy; Extracellular; Receptor; Biology; Chemistry; Medicine; Cell biology; Biochemistry; Internal medicine","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002666502,0.0004311557,0.0003112529,0.0004963136,0.0002630003,0.0004598664,0.0004138919,0.0004363795,0.003760185],"category_scores_gemma":[0.0001309876,0.0001907184,0.0003145384,0.0003949806,0.000272354,0.0003487765,0.0003365908,0.0007097989,0.001023566],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009714651,"about_ca_system_score_gemma":0.0006958191,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002157614,"about_ca_topic_score_gemma":0.001615371,"domain_scores_codex":[0.9998534,0.00002408038,0.00001160558,0.00003017356,0.00005252175,0.00002819395],"domain_scores_gemma":[0.9999349,0.000006887597,0.00001498907,0.000008898808,0.00001601252,0.00001830769],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003685905,0.00005870429,0.0002617889,0.0001361777,0.00002388492,0.0001719339,0.00004391388,0.0004237582,0.9745492,0.002342637,0.003298569,0.01832074],"study_design_scores_gemma":[0.00007709318,0.0003123588,0.00119033,0.00001420926,0.00003478048,0.001729879,0.00002175266,0.001956599,0.9617902,0.0001497846,0.03270932,0.00001383319],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8346639,0.03761813,0.06936464,0.003069027,0.0009648495,0.000482734,0.003491962,0.002841177,0.04750359],"genre_scores_gemma":[0.946901,0.007907907,0.01793384,0.0003101501,0.00004622322,0.000118015,0.002214554,0.0002037466,0.02436464],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003760185,"threshold_uncertainty_score":0.01257908,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04099871369861158,"score_gpt":0.3359801257257002,"score_spread":0.2949814120270886,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}