{"id":"W4405181578","doi":"10.1158/1538-8514.cancerchem24-ia022","title":"Abstract IA022: DYP688, a first-in-class PMEL17-targeted antibody drug conjugate delivering a Gq/11-specific inhibitor for the treatment of metastatic uveal melanoma","year":2024,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"GNAQ; Cancer research; Melanoma; Antibody-drug conjugate; Cancer; In vivo; Medicine; Antibody; Biology; Monoclonal antibody; Internal medicine; Immunology; Mutation","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000203093,0.0003088185,0.0004888789,0.0001729599,0.0001123609,0.0000569478,0.0001688398,0.00006636369,0.0001549093],"category_scores_gemma":[0.000005523843,0.0001984991,0.0003662733,0.0003319932,0.0001693295,0.00004625059,0.00003054379,0.0001927356,0.00001426567],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002605174,"about_ca_system_score_gemma":0.0002330429,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00102085,"about_ca_topic_score_gemma":0.0005111988,"domain_scores_codex":[0.9981347,0.00004832342,0.0004675772,0.0003979539,0.0004551848,0.0004962053],"domain_scores_gemma":[0.9989746,0.0003827602,0.00007469977,0.0003276837,0.0001303209,0.0001100001],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.004177708,0.001530792,0.007956596,0.002832345,0.005575379,0.002023023,0.009312254,0.001418979,0.8155148,0.002204429,0.0006931,0.1467606],"study_design_scores_gemma":[0.004154207,0.00133485,0.01190505,0.0008031339,0.0007944024,0.00005101276,0.000519068,0.02419051,0.2636941,0.0003050261,0.6917839,0.0004647334],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8940468,0.09798036,0.0006388148,0.005206198,0.0004071506,0.001314351,0.000220725,0.00004105551,0.0001444999],"genre_scores_gemma":[0.9799925,0.01809294,0.0004571906,0.0003383951,0.0001975514,0.0002698792,0.00007077448,0.00006917122,0.0005115906],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6910908,"threshold_uncertainty_score":0.8094558,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04368181140493892,"score_gpt":0.3469486631572006,"score_spread":0.3032668517522617,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}