{"id":"W4405181578","doi":"10.1158/1538-8514.cancerchem24-ia022","title":"Abstract IA022: DYP688, a first-in-class PMEL17-targeted antibody drug conjugate delivering a Gq/11-specific inhibitor for the treatment of metastatic uveal melanoma","year":2024,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"GNAQ; Cancer research; Melanoma; Antibody-drug conjugate; Cancer; In vivo; Medicine; Antibody; Biology; Monoclonal antibody; Internal medicine; Immunology; Mutation","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001261485,0.0004250621,0.0002273146,0.0002408368,0.00009580777,0.0002318334,0.0002774391,0.0002921525,0.001226828],"category_scores_gemma":[0.00007354714,0.0001176214,0.0001264134,0.0001364396,0.0001156664,0.0001390245,0.0001483013,0.0004460285,0.0005284006],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003899158,"about_ca_system_score_gemma":0.0002726637,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005722806,"about_ca_topic_score_gemma":0.0005322136,"domain_scores_codex":[0.9999348,0.00001103913,0.000004181668,0.00001315047,0.00001624812,0.00002065297],"domain_scores_gemma":[0.9999715,0.000002116441,0.000008424438,0.000002231521,0.000004875151,0.00001073326],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000868321,0.000347417,0.0004776783,0.0001280876,0.00001840265,0.0001898631,0.00002218697,0.0005449868,0.9750845,0.0002129763,0.0008438043,0.02126181],"study_design_scores_gemma":[0.0006069281,0.006179607,0.002920402,0.00001112773,0.00004539495,0.001263095,0.00001032328,0.002092095,0.9758649,0.00003228924,0.01096572,0.000008119972],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9830791,0.00352244,0.005924773,0.0002266568,0.00007891596,0.0003797182,0.0008267664,0.0002635295,0.005698152],"genre_scores_gemma":[0.9900969,0.001251456,0.002884183,0.00007657006,0.00002033732,0.0001057396,0.001046309,0.00002655633,0.004491915],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001226828,"threshold_uncertainty_score":0.004104197,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04368181140493892,"score_gpt":0.3469486631572006,"score_spread":0.3032668517522617,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}