{"id":"W4405181601","doi":"10.1158/1538-8514.cancerchem24-pr004","title":"Abstract PR004: Brain penetrant allosteric EGFR inhibitors for NSCLC","year":2024,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Erlotinib; T790M; Osimertinib; Gefitinib; Cancer research; Pharmacology; Epidermal growth factor receptor; EGFR inhibitors; In vivo; Kinome; Mutant; Medicine; Chemistry; Allosteric regulation; Kinase; Cancer; Biology; Internal medicine; Receptor; Biochemistry; Gene; Genetics","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002833561,0.000748668,0.0003135369,0.0007451344,0.0003302818,0.000762735,0.001237578,0.0009485462,0.06006686],"category_scores_gemma":[0.0002763085,0.0001514062,0.0002980519,0.0004517656,0.0002759637,0.0006367392,0.0004513287,0.0008783785,0.01618793],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007358852,"about_ca_system_score_gemma":0.0006980022,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001301684,"about_ca_topic_score_gemma":0.002908314,"domain_scores_codex":[0.9998677,0.00001123913,0.000007127038,0.00002289253,0.0000688157,0.00002228222],"domain_scores_gemma":[0.9999112,0.000007851224,0.00001170178,0.000004926439,0.00003246106,0.00003187391],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003780262,0.0001531347,0.000222657,0.0006660528,0.00001539836,0.0006873608,0.00002440503,0.0003369444,0.02746651,0.005670816,0.6684133,0.2959655],"study_design_scores_gemma":[0.0002461614,0.0006568806,0.001126852,0.0001248893,0.00002830085,0.001055295,0.00002416099,0.0003941778,0.01202607,0.001064825,0.983232,0.00002035456],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"other","genre_gemma":"empirical","genre_scores_codex":[0.04121896,0.1277008,0.01637264,0.06221882,0.06992328,0.001672989,0.007923043,0.007673823,0.6652958],"genre_scores_gemma":[0.06668942,0.04816577,0.004014349,0.004942459,0.00569683,0.0001737471,0.002745094,0.0001746216,0.8673977],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.06006686,"threshold_uncertainty_score":0.2009436,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02620718297179474,"score_gpt":0.3585469413050479,"score_spread":0.3323397583332532,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}