{"id":"W4405181965","doi":"10.1158/1538-8514.cancerchem24-ia003","title":"Abstract IA003: Synthetic lethality: Pathways to therapeutic discovery","year":2024,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute","funders":"","keywords":"Synthetic lethality; Computational biology; Cancer; Context (archaeology); Drug discovery; Genome; Chromatin; Biology; CRISPR; DNA repair; Bioinformatics; DNA; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009520806,0.0009102407,0.0004997465,0.0007865581,0.0004152629,0.002774224,0.00071366,0.00106502,0.02337355],"category_scores_gemma":[0.001048681,0.0002081743,0.0003722464,0.0004427947,0.001093902,0.001255086,0.001154526,0.002169284,0.006481698],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001976416,"about_ca_system_score_gemma":0.001174565,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004537507,"about_ca_topic_score_gemma":0.0005985473,"domain_scores_codex":[0.9995943,0.0001084093,0.00001837501,0.00004938986,0.0001746447,0.00005489089],"domain_scores_gemma":[0.9996436,0.0000759555,0.00007367696,0.00003073847,0.00007742287,0.00009863036],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.001233296,0.0003062736,0.0007567102,0.001077973,0.00004527312,0.0008264701,0.0001655458,0.001483113,0.1711637,0.2125011,0.2289935,0.3814471],"study_design_scores_gemma":[0.0001987886,0.000906956,0.001546722,0.0002101616,0.00004777907,0.001652047,0.0001309622,0.002505041,0.09688438,0.06534021,0.8305148,0.00006212027],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"other","genre_gemma":"empirical","genre_scores_codex":[0.05316406,0.1082499,0.1848194,0.1853911,0.01482406,0.0009489884,0.005404791,0.008044955,0.4391528],"genre_scores_gemma":[0.4362331,0.09951027,0.0595038,0.02158845,0.004489093,0.0007071445,0.003125168,0.0008030075,0.3740399],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.02337355,"threshold_uncertainty_score":0.07819229,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02024564830007196,"score_gpt":0.3161788515262899,"score_spread":0.2959332032262179,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}