{"id":"W4405182115","doi":"10.1158/1538-8514.cancerchem24-a009","title":"Abstract A009: Genetic disruption of CAPNS1 impedes triple-negative breast cancer metastasis: A case for selective calpain-1/2 inhibitors","year":2024,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Calpain Protease Function and Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Calpain; Cancer research; Biology; Metastasis; Cancer; Cell biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001904012,0.000276164,0.0002331807,0.0001171403,0.0001094637,0.00004976954,0.00009216345,0.0002134051,0.00004541308],"category_scores_gemma":[0.00001696701,0.000245975,0.0003007023,0.0002847983,0.0001244838,0.00001105991,0.00003266291,0.0001344632,0.000001839031],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001251373,"about_ca_system_score_gemma":0.0003331744,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004587807,"about_ca_topic_score_gemma":0.0003617654,"domain_scores_codex":[0.9985618,0.0000931655,0.0003631023,0.0004935216,0.0002008779,0.0002875513],"domain_scores_gemma":[0.9991875,0.00003226907,0.0001418469,0.0002422202,0.0003068538,0.00008926105],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005077791,0.00008806743,0.0001808656,0.000297195,0.001173781,0.00005610867,0.0003747999,0.001432639,0.9121584,0.00007669986,0.0006438738,0.08300973],"study_design_scores_gemma":[0.001269536,0.0003046406,0.001709963,0.0001688472,0.0006731803,0.0003209642,0.0003642763,0.003211412,0.9769836,0.00043515,0.01406525,0.0004931882],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9383626,0.02740946,0.02934206,0.0008981868,0.0009558597,0.00155711,0.001332866,0.0000636593,0.00007819566],"genre_scores_gemma":[0.996899,0.0009444262,0.0005520144,0.0003293627,0.0003828432,0.0005504994,0.00007957973,0.00007204329,0.0001902137],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08251654,"threshold_uncertainty_score":0.9999992,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01612840961100727,"score_gpt":0.30366891695898,"score_spread":0.2875405073479727,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}