{"id":"W4405182221","doi":"10.1158/1538-8514.cancerchem24-pr002","title":"Abstract PR002: EP300 loss of function is a pan-cancer sensitizer to BET inhibition","year":2024,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Google (Canada)","funders":"","keywords":"Synthetic lethality; Cancer; Cancer research; Biology; Loss function; Regulator; DNA replication; Cancer cell; Gene; Genetics; Phenotype; DNA repair","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009077971,0.0003743705,0.0003170774,0.0002768961,0.0001539314,0.0002855746,0.0003540878,0.0004657573,0.008873737],"category_scores_gemma":[0.00009822511,0.000115133,0.0002320592,0.0001830663,0.0001554434,0.0002083864,0.0001556914,0.001095626,0.001612179],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003020563,"about_ca_system_score_gemma":0.0001611595,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000542709,"about_ca_topic_score_gemma":0.0009166556,"domain_scores_codex":[0.9999154,0.000008294613,0.000005566993,0.00001639548,0.00003281071,0.0000215437],"domain_scores_gemma":[0.9999545,0.000009240461,0.000007491436,0.00000653482,0.000005496597,0.00001674309],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005006106,0.0002059369,0.0001755736,0.0000602691,0.00001405337,0.0001385335,0.000008865446,0.0001606606,0.9891522,0.0002267428,0.001560711,0.007795951],"study_design_scores_gemma":[0.0001161446,0.001763839,0.003321709,0.000009845501,0.00002627416,0.0008134156,0.00002123754,0.001287047,0.9791462,0.0001139328,0.01337059,0.000009858647],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9580561,0.005573747,0.005262516,0.001090562,0.0003474728,0.0002553744,0.00389931,0.001445597,0.0240693],"genre_scores_gemma":[0.9714533,0.001647303,0.001760268,0.0003758447,0.00003042547,0.00009841762,0.002889297,0.00007748172,0.02166757],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008873737,"threshold_uncertainty_score":0.02968562,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01711549144858129,"score_gpt":0.2877026725892809,"score_spread":0.2705871811406997,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}