{"id":"W4405182393","doi":"10.1158/1538-8514.cancerchem24-ia023","title":"Abstract IA023: Dual-drug ADC platform for effective and safe cancer treatment","year":2024,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Antibody-drug conjugate; Tolerability; Drug; Cancer; Pharmacology; Cancer research; Drug resistance; Internal medicine; Antibody; Immunology; Biology; Adverse effect; Monoclonal antibody","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001834262,0.0004042935,0.0003635296,0.000333024,0.0001896603,0.0005720153,0.000367455,0.0005509678,0.004675773],"category_scores_gemma":[0.0001265563,0.0001799022,0.000196864,0.0002452235,0.0001424329,0.000420244,0.0003810018,0.0006756773,0.001729245],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006016748,"about_ca_system_score_gemma":0.0005670502,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009255744,"about_ca_topic_score_gemma":0.001138796,"domain_scores_codex":[0.999904,0.000009358047,0.000005949131,0.00002004382,0.0000348122,0.00002576404],"domain_scores_gemma":[0.999952,0.000002982712,0.00001005887,0.00000418038,0.00001624816,0.00001463998],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003077809,0.0001288619,0.0002088769,0.0002143305,0.00001732208,0.0001699223,0.00002836764,0.00112655,0.9322333,0.001957719,0.00714618,0.05646075],"study_design_scores_gemma":[0.0001469197,0.0009169165,0.001044912,0.00002606998,0.00004637341,0.0006447863,0.00001805646,0.01039936,0.9173247,0.000347267,0.06905288,0.00003171165],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6783262,0.047802,0.1637602,0.004154098,0.001436133,0.001425402,0.005415901,0.0056125,0.09206761],"genre_scores_gemma":[0.9290577,0.006837671,0.03731669,0.000670235,0.0001074559,0.000312812,0.001591825,0.0001221321,0.02398348],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004675773,"threshold_uncertainty_score":0.01564205,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05581262807661499,"score_gpt":0.4060311569159849,"score_spread":0.3502185288393699,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}