{"id":"W4405183298","doi":"10.3390/biomedicines12122794","title":"Exploration of Novel Biomarkers for Neurodegenerative Diseases Using Proteomic Analysis and Ligand-Binding Assays","year":2024,"lang":"en","type":"article","venue":"Biomedicines","topic":"Advanced Biosensing Techniques and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"AbbVie Canada","keywords":"Biomarker; Disease; Antibody microarray; Osteopontin; Biomarker discovery; Medicine; Proteomics; Parkinson's disease; Microarray; Multiple sclerosis; Bioinformatics; Computational biology; Immunology; Antibody; Biology; Pathology; Gene expression; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006295247,0.00008175322,0.0001094973,0.0001444171,0.00005453174,0.00001447085,0.00003627877,0.00004577343,3.075901e-7],"category_scores_gemma":[0.00003386536,0.00006577953,0.00005963664,0.0003309892,0.00009619835,0.000007731671,0.00002615557,0.00001497371,5.143244e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006239858,"about_ca_system_score_gemma":0.00002459983,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009421798,"about_ca_topic_score_gemma":0.000003456175,"domain_scores_codex":[0.9995043,0.000006963817,0.0001339947,0.0002302492,0.00004798512,0.00007652214],"domain_scores_gemma":[0.9997367,0.0000141766,0.00005035117,0.0001118771,0.00005568435,0.0000312315],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000179817,0.00001835203,0.0002197334,0.00004239552,0.0001454094,2.138337e-7,0.00001891497,0.00002191705,0.9976831,0.0001256858,0.0001485659,0.001557719],"study_design_scores_gemma":[0.0001727622,0.0001309381,0.0002385259,0.00004606739,0.0003681979,0.000003071224,0.00005465292,0.01448457,0.9830177,0.0001589808,0.001226064,0.00009847728],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5424404,0.0004106574,0.45656,0.0001929791,0.00003591679,0.0002220987,0.0001174047,0.00001691566,0.000003738696],"genre_scores_gemma":[0.9630792,0.0001256626,0.03625058,0.00002147905,0.0001516876,0.00004141652,0.0002820773,0.00001172554,0.00003618595],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4206389,"threshold_uncertainty_score":0.2682411,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03812096114114531,"score_gpt":0.3373875557860943,"score_spread":0.2992665946449489,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}