{"id":"W4405183426","doi":"10.1101/2024.12.06.627213","title":"Age-related remodeling of the glycocalyx drives T cell exhaustion","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Glycocalyx; Sialic acid; Immune system; Glycan; Cell biology; Cell; T cell; Downregulation and upregulation; Biology; Immunology; Biochemistry; Gene; Glycoprotein","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001983874,0.0004008087,0.0002921723,0.0003196351,0.00009961729,0.000303805,0.0001875473,0.0003938941,0.0009013094],"category_scores_gemma":[0.0001298961,0.0002048695,0.0003325779,0.0001377919,0.0002498154,0.0002753524,0.00032613,0.0008231598,0.0002272807],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000254006,"about_ca_system_score_gemma":0.0001047515,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002839778,"about_ca_topic_score_gemma":0.0003147448,"domain_scores_codex":[0.9998392,0.00002081564,0.00001615571,0.0000395388,0.00002996821,0.00005429238],"domain_scores_gemma":[0.9997483,0.00002006679,0.0001071839,0.0000246519,0.00002272118,0.00007710999],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001034743,0.00002396376,0.0003998617,0.00001222136,0.000003439129,0.00004474957,0.000009113442,0.00003501871,0.9988806,0.00004221792,0.00001982987,0.0004255736],"study_design_scores_gemma":[0.00003161662,0.001321274,0.02649518,0.0000143319,0.00003491609,0.0006760891,0.00008418452,0.001796136,0.967298,0.0002216546,0.002014843,0.00001186256],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976463,0.000565268,0.001153907,0.0000422264,0.00001866224,0.00001197379,0.0001830352,0.00003877212,0.0003398043],"genre_scores_gemma":[0.9975365,0.0003204707,0.0005279001,0.00006745105,0.00001566615,0.00001766803,0.0002097114,0.00001303781,0.001291497],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009013094,"threshold_uncertainty_score":0.003015161,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01089818898212744,"score_gpt":0.2340440323089197,"score_spread":0.2231458433267922,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}