{"id":"W4405189264","doi":"10.1158/2767-9764.crc-24-0568","title":"First-in-Human Study of 23ME-00610, an Antagonistic Antibody for Genetically Validated CD200R1 Immune Checkpoint, in Participants with Advanced Solid Malignancies","year":2024,"lang":"en","type":"article","venue":"Cancer Research Communications","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; Princess Margaret Cancer Centre","funders":"","keywords":"Tolerability; Pharmacodynamics; Adverse effect; Medicine; Rash; Pharmacokinetics; Dosing; Immune system; Cmax; Internal medicine; Oncology; Pharmacology; Maximum tolerated dose; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001145051,0.000174016,0.0002973504,0.0005506823,0.0004952635,0.0001788644,0.00117803,0.00004806898,0.0000505175],"category_scores_gemma":[0.0005725228,0.0001616196,0.00004072089,0.001495814,0.0003666064,0.0003353801,0.0002941759,0.0004652321,0.000008233925],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000123269,"about_ca_system_score_gemma":0.0003323159,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002000797,"about_ca_topic_score_gemma":0.004325156,"domain_scores_codex":[0.9966758,0.0009177434,0.0007290824,0.0005709926,0.0005412283,0.0005651305],"domain_scores_gemma":[0.9971054,0.0007806864,0.00009779901,0.001601859,0.0002854159,0.0001288661],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001226963,0.0008490748,0.0003373298,0.00009571987,0.000006505614,0.00001948015,0.00173684,0.004585423,0.9815848,0.01031915,0.000007252815,0.0003357645],"study_design_scores_gemma":[0.001790408,0.001534954,0.004591795,0.0003133233,0.00001673664,0.000004231281,0.0007398455,0.06471703,0.9244234,0.0009606667,0.0006740759,0.0002335474],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953679,0.0002892621,0.0005936015,0.00114352,0.00007625965,0.00220327,0.00007473586,0.00008874133,0.000162751],"genre_scores_gemma":[0.9967108,0.0009192781,0.0004192822,0.00003528276,0.00001835523,0.001639782,0.00003157317,0.00004947472,0.00017617],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06013161,"threshold_uncertainty_score":0.6590657,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2260719129356011,"score_gpt":0.4938563121146675,"score_spread":0.2677843991790664,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}