{"id":"W4405189264","doi":"10.1158/2767-9764.crc-24-0568","title":"First-in-Human Study of 23ME-00610, an Antagonistic Antibody for Genetically Validated CD200R1 Immune Checkpoint, in Participants with Advanced Solid Malignancies","year":2024,"lang":"en","type":"article","venue":"Cancer Research Communications","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; Princess Margaret Cancer Centre","funders":"","keywords":"Tolerability; Pharmacodynamics; Adverse effect; Medicine; Rash; Pharmacokinetics; Dosing; Immune system; Cmax; Internal medicine; Oncology; Pharmacology; Maximum tolerated dose; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002418437,0.0010474,0.001161629,0.0002003819,0.0005898199,0.0005965377,0.0005599065,0.001038493,0.00363856],"category_scores_gemma":[0.0008562188,0.0004915304,0.0007360405,0.0001756059,0.0005814288,0.0005999849,0.0003056008,0.001998787,0.0009884523],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005927074,"about_ca_system_score_gemma":0.001124349,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004638176,"about_ca_topic_score_gemma":0.001799791,"domain_scores_codex":[0.9994857,0.0002639098,0.00002114248,0.00008948904,0.00006276736,0.00007700772],"domain_scores_gemma":[0.9993361,0.00009686025,0.0001566858,0.00006651396,0.00006834912,0.0002755581],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5707382,0.08963098,0.04312649,0.001013509,0.002133659,0.0004641081,0.0006699541,0.001445747,0.180957,0.0002457491,0.003651132,0.1059235],"study_design_scores_gemma":[0.1297663,0.8179185,0.03488312,0.00003150149,0.0005640677,0.0003944912,0.0001025251,0.0005882916,0.0105494,0.0001753276,0.004998043,0.00002839595],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958151,0.0007549475,0.0004738523,0.0001212886,0.00003989705,0.001554346,0.0005093694,0.00005788772,0.0006732458],"genre_scores_gemma":[0.9944074,0.0003306652,0.001201494,0.0003800986,0.00006267259,0.001411354,0.0005399184,0.00001832346,0.001648051],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00363856,"threshold_uncertainty_score":0.01279008,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2260719129356011,"score_gpt":0.4938563121146675,"score_spread":0.2677843991790664,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}