{"id":"W4405199316","doi":"10.1016/j.mucimm.2024.12.002","title":"Early life microbiota colonization programs nociceptor sensitivity by regulating NGF production in mast cells","year":2024,"lang":"en","type":"article","venue":"Mucosal Immunology","topic":"Dermatology and Skin Diseases","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research; Institute of Neurosciences, Mental Health and Addiction; Cumming School of Medicine, University of Calgary; Crohn's and Colitis Canada; Canadian Association of Gastroenterology","keywords":"Colonization; Nociceptor; Inflammation; Nerve growth factor; Biology; Microbiology; Immunology; Cell biology; Medicine; Receptor; Biochemistry; Nociception","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001605868,0.0003943663,0.0003103104,0.000276542,0.0001853835,0.0003985619,0.000191229,0.0003917343,0.001226562],"category_scores_gemma":[0.0002771335,0.0001454,0.0003865623,0.00009580504,0.0003243895,0.0003991385,0.0004319884,0.0008086933,0.0002613074],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003485584,"about_ca_system_score_gemma":0.0003051685,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006316773,"about_ca_topic_score_gemma":0.001106107,"domain_scores_codex":[0.9998178,0.00002336834,0.00001512808,0.00004485718,0.00003841304,0.00006052691],"domain_scores_gemma":[0.9997117,0.00002494167,0.0001014258,0.00001698919,0.00003929792,0.0001056339],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004340438,0.00003449808,0.001588782,0.0001101242,0.000008493426,0.0001103026,0.00004082201,0.00003464348,0.9948558,0.0000657133,0.00004597277,0.002670799],"study_design_scores_gemma":[0.0001125705,0.002289354,0.2298174,0.0001275711,0.000117633,0.0006874491,0.0005087553,0.001256692,0.7606761,0.0004722633,0.003898105,0.00003614222],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898973,0.006222229,0.002423825,0.0001901551,0.00005876653,0.00002170471,0.0002899951,0.00008220665,0.0008137171],"genre_scores_gemma":[0.992336,0.003345397,0.002070426,0.00009543618,0.00003451337,0.00004917537,0.0002391738,0.0000256707,0.001804249],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001226562,"threshold_uncertainty_score":0.004103303,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009167355383904837,"score_gpt":0.2404028053038502,"score_spread":0.2312354499199454,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}