{"id":"W4405208134","doi":"10.1177/00368504241266357","title":"The multifaceted helical net of amphipathic alpha-helices; the next dimension of the helical peptide wheel","year":2024,"lang":"en","type":"article","venue":"Science Progress","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; American Heart Association","keywords":"Amphiphile; Peptide; Chemistry; Helix (gastropod); Peptide sequence; Amino acid; Alpha helix; Biophysics; Protein structure; Crystallography; Stereochemistry; Biochemistry; Copolymer; Biology; Organic chemistry; Polymer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009561371,0.0001155953,0.000130271,0.0000213853,0.0003209761,0.0001092866,0.0009301358,0.00007463497,0.000008390779],"category_scores_gemma":[0.0003070321,0.00004771337,0.0002014524,0.0005810733,0.002333381,0.000008801457,0.0004604337,0.000139729,0.000005176214],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001163802,"about_ca_system_score_gemma":0.0001222204,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002717777,"about_ca_topic_score_gemma":0.00001986794,"domain_scores_codex":[0.9985313,0.00007412161,0.000264766,0.0003599503,0.0004917415,0.0002781065],"domain_scores_gemma":[0.9990284,0.00008337794,0.00009601382,0.0005856755,0.0001415024,0.0000649722],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001535597,0.00004052223,0.0009845856,0.00001822982,0.00002395605,3.655932e-7,0.00008821166,0.000008407694,0.9734718,0.000203266,0.00022666,0.02491859],"study_design_scores_gemma":[0.00007876533,0.0000583634,0.00331126,0.0000903605,0.00004114557,0.000005772975,0.0002004975,0.005425419,0.974818,0.0001110717,0.0157662,0.00009313276],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907528,0.005237359,0.00002901139,0.003564416,0.0001308761,0.000162298,0.000007515881,0.00000865625,0.0001071114],"genre_scores_gemma":[0.999309,0.0002308056,0.0001004108,0.0001076698,0.0000866296,0.00002092787,0.000002393231,0.000007934165,0.0001342457],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02482546,"threshold_uncertainty_score":0.8597439,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01364628384033505,"score_gpt":0.2813346595099795,"score_spread":0.2676883756696445,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}