{"id":"W4405212244","doi":"10.26434/chemrxiv-2024-3mcc5-v3","title":"Merging Photoexcited Nitroarenes with Lewis Acid Catalysis for the Anti-Markovnikov Oxidation of Alkenes","year":2024,"lang":"en","type":"preprint","venue":"ChemRxiv","topic":"Radical Photochemical Reactions","field":"Chemistry","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; American Chemical Society Petroleum Research Fund; National Institutes of Health; York University","keywords":"Chemistry; Markovnikov's rule; Lewis acids and bases; Aldehyde; Ketone; Catalysis; Lewis acid catalysis; Nucleophile; Selectivity; Organic chemistry; Acetone; Solvent; Medicinal chemistry; Combinatorial chemistry; Regioselectivity","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001807919,0.0004467798,0.0006047946,0.0001195885,0.0001283679,0.0001055392,0.0006829093,0.0004277701,0.0002983966],"category_scores_gemma":[0.0003868938,0.0003111298,0.0004720173,0.0003346931,0.000306576,0.00005424235,0.0004582925,0.0007909832,0.00001269845],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001515813,"about_ca_system_score_gemma":0.0001953727,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000343148,"about_ca_topic_score_gemma":0.00002106117,"domain_scores_codex":[0.997926,0.00001124905,0.0005386097,0.0007652811,0.0004164597,0.0003423751],"domain_scores_gemma":[0.9974795,0.0006074957,0.0003910812,0.001150866,0.0002560063,0.0001150628],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006267056,0.00008547235,0.0001317683,0.001987291,0.0009224404,0.000002755874,0.0001509825,0.0001659306,0.9939499,0.00004766001,0.001597665,0.00089545],"study_design_scores_gemma":[0.0002667945,0.000007614271,0.00003959761,0.0006290933,0.001043685,0.000004619846,0.0001839818,0.002542577,0.9896743,0.001558964,0.00369325,0.0003555471],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926201,0.002467235,0.0007209054,0.00101651,0.0002335513,0.0005007471,0.0001027811,0.0002320785,0.002106119],"genre_scores_gemma":[0.9958373,0.0001650582,0.0008360391,0.00003043268,0.0003220542,0.0009614137,0.0009032647,0.0001046126,0.0008398184],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004275637,"threshold_uncertainty_score":0.9999341,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01622726965161062,"score_gpt":0.2612107554546171,"score_spread":0.2449834858030065,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}