{"id":"W4405215118","doi":"10.3389/fcell.2024.1504098","title":"Protein “purity,” proteoforms, and the albuminome: critical observations on proteome and systems complexity","year":2024,"lang":"en","type":"article","venue":"Frontiers in Cell and Developmental Biology","topic":"Advanced Proteomics Techniques and Applications","field":"Chemistry","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Brock University","funders":"Natural Sciences and Engineering Research Council of Canada; Brock University; University of Technology Sydney","keywords":"Proteome; Computational biology; Chemistry; Cell biology; Biology; Computer science; Bioinformatics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006237785,0.0005638102,0.000772242,0.001951562,0.0007448611,0.00284946,0.0007659898,0.0009156386,0.0009010055],"category_scores_gemma":[0.006044665,0.00045323,0.0003166207,0.001305499,0.005918721,0.004939979,0.001529749,0.003348628,0.0002766945],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001546454,"about_ca_system_score_gemma":0.0005698156,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006521204,"about_ca_topic_score_gemma":0.0005669732,"domain_scores_codex":[0.997211,0.0009577137,0.0001834361,0.0004957303,0.001017291,0.0001347786],"domain_scores_gemma":[0.993586,0.004183767,0.0007662804,0.0004790687,0.0008086633,0.0001761901],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001005172,0.0002212942,0.03770738,0.003799622,0.0004891505,0.001128634,0.002786089,0.004122992,0.5496188,0.1216663,0.01420098,0.2632534],"study_design_scores_gemma":[0.00003079356,0.0008070745,0.1278859,0.001083261,0.0003388369,0.006958131,0.002753807,0.01906996,0.4032065,0.2745044,0.1629325,0.0004288291],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.3144358,0.3899098,0.2256562,0.04587383,0.001789616,0.0001524887,0.0009324756,0.0009220387,0.02032774],"genre_scores_gemma":[0.8317674,0.09057786,0.06433921,0.006425934,0.003020738,0.000102134,0.0004875052,0.0003137315,0.002965451],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.006237785,"threshold_uncertainty_score":0.03298897,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02852783062249743,"score_gpt":0.2690408076898896,"score_spread":0.2405129770673922,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}