{"id":"W4405218591","doi":"10.1101/2024.12.09.627393","title":"The CECR2 bromodomain displays distinct binding modes to select for acetylated histone proteins versus non-histone ligands","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Lethbridge","funders":"","keywords":"Bromodomain; Acetylation; Histone; Histone methyltransferase; Histone H2A; Histone H3; Chemistry; Epigenetics; Histone methylation; Isothermal titration calorimetry; Biochemistry; Biology; Cell biology; DNA methylation; Gene expression; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000263508,0.0003049004,0.0002861166,0.0001906908,0.0001349255,0.0002046089,0.0003244832,0.000308279,0.001445738],"category_scores_gemma":[0.0002505501,0.0001543244,0.0003063485,0.000127848,0.0001869775,0.0001516249,0.0002475702,0.0003527912,0.0005413394],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002528074,"about_ca_system_score_gemma":0.0000887533,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004394391,"about_ca_topic_score_gemma":0.0005739916,"domain_scores_codex":[0.9997523,0.00004759742,0.00001143489,0.0000582795,0.00007351491,0.00005683544],"domain_scores_gemma":[0.9998584,0.00003297912,0.00002567601,0.00001637344,0.0000258182,0.00004079433],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008377499,0.000009728571,0.0002337772,0.00001726373,0.0000047422,0.00001932537,0.000004724604,0.00004646773,0.9991735,0.00002435254,0.00003572083,0.0003466309],"study_design_scores_gemma":[0.00001687616,0.0001571305,0.004667979,0.000004096548,0.000008817234,0.0003597148,0.00002195056,0.00292961,0.989862,0.00002419075,0.001936781,0.0000108417],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936321,0.0008901009,0.00396808,0.00007634427,0.00002766246,0.00001665931,0.0003050618,0.00006996677,0.001014018],"genre_scores_gemma":[0.9947784,0.0001660263,0.003046378,0.0001357605,0.000006361758,0.00001795862,0.0005753142,0.00002086736,0.001252963],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001445738,"threshold_uncertainty_score":0.0048365,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01182939874056242,"score_gpt":0.2618042486428744,"score_spread":0.249974849902312,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}