{"id":"W4405220977","doi":"10.1093/nar/gkae1115","title":"MIBiG 4.0: advancing biosynthetic gene cluster curation through global collaboration","year":2024,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":206,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; McMaster University; University of Manitoba; Simon Fraser University; University of Northern British Columbia","funders":"National Science Foundation Graduate Research Fellowship Program; SINTEF Industri; HORIZON EUROPE European Innovation Council; National Center for Complementary and Integrative Health; National Key Research and Development Program of China; European Regional Development Fund; Staatssekretariat für Bildung, Forschung und Innovation; Fundação para a Ciência e a Tecnologia; Japan Society for the Promotion of Science; National Health and Medical Research Council; Biotechnology and Biological Sciences Research Council; Medical Research Council; Natural Sciences and Engineering Research Council of Canada; HORIZON EUROPE Framework Programme; Horizon 2020 Framework Programme; National Institute of Environmental Health Sciences; Office of Science; H2020 Marie Skłodowska-Curie Actions; University of Illinois at Urbana-Champaign; National Agri-Food Biotechnology Institute; Directorate for Biological Sciences; National Institutes of Health; Kementerian Pendidikan, Kebudayaan, Riset, dan Teknologi; Agencia Nacional de Investigación y Desarrollo; Fulbright Association; Junta de Andalucía; Novo Nordisk Fonden; National Estuarine Research Reserve System; Universität des Saarlandes; Shanghai Jiao Tong University; Ministry of Higher Education and Scientific Research; Ministry of Education, India; National Institute of General Medical Sciences; Leids Universitair Medisch Centrum; National Natural Science Foundation of China; National Research Foundation of Korea; Deutsche Forschungsgemeinschaft; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Hans-Fischer-Gesellschaft; Consejo Nacional de Ciencia y Tecnología; Fonds Wetenschappelijk Onderzoek; Fonds National de la Recherche Luxembourg; H2020 European Research Council; Australian Government; University of Sydney; Danmarks Grundforskningsfond; U.S. Department of Agriculture; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Universiteit Leiden; University Grants Commission of Bangladesh; National Science Foundation; UK Research and Innovation; Division of Chemical, Bioengineering, Environmental, and Transport Systems; Department of Biotechnology, Ministry of Science and Technology, India; Department for Environment, Food and Rural Affairs, UK Government; Ministry of Education and Science of Ukraine; Werner Siemens-Stiftung; Leibniz-Gemeinschaft; Agence Nationale de la Recherche; Emory University; Ministerio de Ciencia, Innovación y Universidades; Government of the United Kingdom; University Grants Commission; Badan Riset dan Inovasi Nasional; National Research Foundation; Vlaamse regering; Alexander von Humboldt-Stiftung; Ministry of Science and ICT, South Korea; Novo Nordisk; Deutsches Zentrum für Infektionsforschung; Carlsbergfondet; Innovationsfonden; European Commission; Fundação de Amparo à Pesquisa do Estado de São Paulo; Lembaga Pengelola Dana Pendidikan; Austrian Science Fund; U.S. Department of Energy","keywords":"Biology; Gene cluster; Data curation; Cluster (spacecraft); Computational biology; Gene; Genetics; Data science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001036249,0.0001664023,0.0002246446,0.0001552666,0.0002472163,0.0002600906,0.0001481182,0.0001963533,0.000622304],"category_scores_gemma":[0.0007000464,0.0001234292,0.00008385504,0.001659252,0.00017758,0.00052977,0.0001180445,0.0004656824,0.0008387399],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005456422,"about_ca_system_score_gemma":0.0003662729,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000848356,"about_ca_topic_score_gemma":0.00004828279,"domain_scores_codex":[0.9976443,0.000191446,0.0002961219,0.0005789511,0.0007474527,0.0005417208],"domain_scores_gemma":[0.9987824,0.0001216802,0.00002543803,0.0003997815,0.0005382627,0.0001324186],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003216075,0.00009856655,0.0001620495,0.0003845815,0.00006996337,0.00008727946,0.0004999615,0.00000506335,0.8921986,0.002087763,0.05953927,0.04454533],"study_design_scores_gemma":[0.0007422719,0.0006254521,0.0008004496,0.0007058946,0.00009775356,0.0002730838,0.0006998185,0.003934938,0.5511981,0.002572364,0.4380012,0.0003486389],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9249862,0.004564025,0.0006784212,0.05747125,0.0008795417,0.001233464,0.00008405789,0.0002985557,0.009804424],"genre_scores_gemma":[0.991829,0.0005108744,0.003980938,0.0004243867,0.0009412365,0.000004824338,0.00005166722,0.00003478677,0.002222287],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3784619,"threshold_uncertainty_score":0.9999392,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0380303185785064,"score_gpt":0.3719305438624363,"score_spread":0.3339002252839299,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}