{"id":"W4405220977","doi":"10.1093/nar/gkae1115","title":"MIBiG 4.0: advancing biosynthetic gene cluster curation through global collaboration","year":2024,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":206,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; McMaster University; University of Manitoba; Simon Fraser University; University of Northern British Columbia","funders":"National Science Foundation Graduate Research Fellowship Program; SINTEF Industri; HORIZON EUROPE European Innovation Council; National Center for Complementary and Integrative Health; National Key Research and Development Program of China; European Regional Development Fund; Staatssekretariat für Bildung, Forschung und Innovation; Fundação para a Ciência e a Tecnologia; Japan Society for the Promotion of Science; National Health and Medical Research Council; Biotechnology and Biological Sciences Research Council; Medical Research Council; Natural Sciences and Engineering Research Council of Canada; HORIZON EUROPE Framework Programme; Horizon 2020 Framework Programme; National Institute of Environmental Health Sciences; Office of Science; H2020 Marie Skłodowska-Curie Actions; University of Illinois at Urbana-Champaign; National Agri-Food Biotechnology Institute; Directorate for Biological Sciences; National Institutes of Health; Kementerian Pendidikan, Kebudayaan, Riset, dan Teknologi; Agencia Nacional de Investigación y Desarrollo; Fulbright Association; Junta de Andalucía; Novo Nordisk Fonden; National Estuarine Research Reserve System; Universität des Saarlandes; Shanghai Jiao Tong University; Ministry of Higher Education and Scientific Research; Ministry of Education, India; National Institute of General Medical Sciences; Leids Universitair Medisch Centrum; National Natural Science Foundation of China; National Research Foundation of Korea; Deutsche Forschungsgemeinschaft; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Hans-Fischer-Gesellschaft; Consejo Nacional de Ciencia y Tecnología; Fonds Wetenschappelijk Onderzoek; Fonds National de la Recherche Luxembourg; H2020 European Research Council; Australian Government; University of Sydney; Danmarks Grundforskningsfond; U.S. Department of Agriculture; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Universiteit Leiden; University Grants Commission of Bangladesh; National Science Foundation; UK Research and Innovation; Division of Chemical, Bioengineering, Environmental, and Transport Systems; Department of Biotechnology, Ministry of Science and Technology, India; Department for Environment, Food and Rural Affairs, UK Government; Ministry of Education and Science of Ukraine; Werner Siemens-Stiftung; Leibniz-Gemeinschaft; Agence Nationale de la Recherche; Emory University; Ministerio de Ciencia, Innovación y Universidades; Government of the United Kingdom; University Grants Commission; Badan Riset dan Inovasi Nasional; National Research Foundation; Vlaamse regering; Alexander von Humboldt-Stiftung; Ministry of Science and ICT, South Korea; Novo Nordisk; Deutsches Zentrum für Infektionsforschung; Carlsbergfondet; Innovationsfonden; European Commission; Fundação de Amparo à Pesquisa do Estado de São Paulo; Lembaga Pengelola Dana Pendidikan; Austrian Science Fund; U.S. Department of Energy","keywords":"Biology; Gene cluster; Data curation; Cluster (spacecraft); Computational biology; Gene; Genetics; Data science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0434438,0.004363039,0.004021368,0.02180577,0.004787168,0.01290918,0.008023128,0.002975123,0.02940752],"category_scores_gemma":[0.09980953,0.002960155,0.003986261,0.0159421,0.002543769,0.01103748,0.02972394,0.005423012,0.04756163],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002428472,"about_ca_system_score_gemma":0.01465702,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004691939,"about_ca_topic_score_gemma":0.007632427,"domain_scores_codex":[0.9758758,0.007630237,0.003561123,0.006147453,0.005421009,0.001364374],"domain_scores_gemma":[0.9410737,0.01416338,0.004227076,0.02196448,0.01222575,0.00634558],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002254852,0.0003247127,0.01112066,0.009152844,0.001399982,0.0008768715,0.008917563,0.003198804,0.04326816,0.02636245,0.7146018,0.1785212],"study_design_scores_gemma":[0.0003286269,0.0001888413,0.005798489,0.001582499,0.0002983249,0.0004789357,0.001112355,0.006617,0.01467599,0.02999086,0.9385504,0.0003777235],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.01546787,0.00416254,0.3466071,0.005368324,0.002307994,0.002263476,0.2670504,0.3270855,0.02968674],"genre_scores_gemma":[0.01758737,0.001599343,0.375234,0.001546547,0.0004022445,0.002759222,0.530756,0.06330277,0.006812532],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.0434438,"threshold_uncertainty_score":0.2297555,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0380303185785064,"score_gpt":0.3719305438624363,"score_spread":0.3339002252839299,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}