{"id":"W4405226809","doi":"10.1093/jac/dkae432","title":"Development and confirmation of humanized plasma and epithelial lining fluid exposures of meropenem, cefiderocol and tobramycin in a standardized neutropenic murine pneumonia model","year":2024,"lang":"en","type":"article","venue":"Journal of Antimicrobial Chemotherapy","topic":"Antibiotics Pharmacokinetics and Efficacy","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Environmental Health Sciences; National Institute of Allergy and Infectious Diseases; Biomedical Advanced Research and Development Authority; Bundesministerium für Bildung und Forschung; European Society of Clinical Microbiology and Infectious Diseases; Public Health Agency of Canada; Department of Health and Social Care; Wellcome Trust; National Institutes of Health; U.S. Department of Health and Human Services; Combating Antibiotic-Resistant Bacteria Biopharmaceutical Accelerator; Bill and Melinda Gates Foundation; Novo Nordisk Fonden; Administration for Strategic Preparedness and Response","keywords":"Tobramycin; Meropenem; Pneumonia; Antibiotics; Neutropenia; Microbiology; Medicine; Biology; Chemotherapy; Internal medicine; Gentamicin; Antibiotic resistance","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002111614,0.0005588321,0.0003989943,0.000286229,0.0001361309,0.0005573932,0.0004703648,0.0006562387,0.00110399],"category_scores_gemma":[0.001263868,0.0002308245,0.000452796,0.0002186893,0.0004851755,0.0004175951,0.0002954128,0.001030225,0.0003445985],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004807917,"about_ca_system_score_gemma":0.0006932321,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004516763,"about_ca_topic_score_gemma":0.0005240584,"domain_scores_codex":[0.9984913,0.0005565769,0.0001378758,0.0002308496,0.0004658005,0.0001176668],"domain_scores_gemma":[0.9992737,0.0001228488,0.0002167565,0.0001807981,0.0001091092,0.0000967283],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001090606,0.0008228294,0.0006247935,0.00009270418,0.00002887971,0.00008496862,0.00007919395,0.0008208965,0.9892895,0.0002146055,0.0003394249,0.006511522],"study_design_scores_gemma":[0.0002344768,0.02094526,0.004138694,0.00001884313,0.0000617196,0.0006275486,0.00005041252,0.002057313,0.9642072,0.00007640581,0.00756669,0.00001553421],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9432624,0.001584046,0.04962566,0.0003353094,0.0001015406,0.001879243,0.001480461,0.0002810046,0.001450314],"genre_scores_gemma":[0.9566626,0.001047586,0.03769619,0.0002352226,0.00003861389,0.0008830329,0.001998362,0.00006200165,0.001376352],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002111614,"threshold_uncertainty_score":0.01116741,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01737048846598391,"score_gpt":0.2884491184223279,"score_spread":0.271078629956344,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}