{"id":"W4405233103","doi":"10.1093/hmg/ddae171","title":"Development of a riboflavin-responsive model of riboflavin transporter deficiency in zebrafish","year":2024,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Metabolism and Genetic Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Ottawa Hospital; Children's Hospital of Eastern Ontario","funders":"Medical Research Council; Engineering and Physical Sciences Research Council; Canadian Institutes of Health Research; European Commission; Canada Foundation for Innovation; Canada First Research Excellence Fund; Canada Research Chairs; National Institutes of Health; Government of Canada; NIHR Cambridge Biomedical Research Centre; Wellcome Trust","keywords":"Riboflavin; Morpholino; Zebrafish; Biology; Gene knockdown; Phenotype; Probenecid; Transporter; Cell biology; Pharmacology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004390409,0.0008224554,0.0007326395,0.0008168097,0.0006837473,0.0007052681,0.001222615,0.001646612,0.003784706],"category_scores_gemma":[0.000292848,0.0005678894,0.0009712037,0.0002406362,0.0006141695,0.0007440446,0.0007567537,0.00256534,0.001514036],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001414853,"about_ca_system_score_gemma":0.001359106,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006719596,"about_ca_topic_score_gemma":0.01108749,"domain_scores_codex":[0.9996087,0.0000234048,0.00003800119,0.0001141919,0.000144681,0.0000710404],"domain_scores_gemma":[0.9997059,0.00003705206,0.00006509628,0.00002541972,0.00005969885,0.0001069254],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001178401,0.00006254513,0.0002317062,0.0001647207,0.00001499338,0.0004200393,0.0001024849,0.0003456711,0.9941507,0.001306078,0.0005265133,0.002556565],"study_design_scores_gemma":[0.0002500404,0.001344539,0.004048268,0.000176454,0.0001860306,0.001401382,0.0002634785,0.007499053,0.9389743,0.0009378085,0.04482022,0.00009841575],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8185693,0.008391294,0.1225843,0.00316575,0.001646666,0.002250027,0.01410804,0.00400849,0.02527617],"genre_scores_gemma":[0.8396121,0.006570271,0.07533022,0.0008516343,0.00006360162,0.002824795,0.005745684,0.0005897562,0.06841192],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006719596,"threshold_uncertainty_score":0.01336098,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01583323930328098,"score_gpt":0.2723592554956923,"score_spread":0.2565260161924113,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}