{"id":"W4405233949","doi":"10.1371/journal.pone.0314655","title":"THUMPD3 regulates alternative splicing of ECM transcripts in human lung cancer cells and promotes proliferation and migration","year":2024,"lang":"en","type":"article","venue":"PLoS ONE","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University","funders":"Canada Foundation for Innovation; Ontario Ministry of Research and Innovation; Natural Sciences and Engineering Research Council of Canada; Cancer Research UK; Wellcome Trust; Wellcome","keywords":"Alternative splicing; RNA splicing; Cell biology; Lung cancer; Cancer research; Biology; Human lung; Computational biology; Medicine; Genetics; Gene; Messenger RNA; RNA; Pathology; Cell culture","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009644448,0.0001946466,0.0001874475,0.0002521956,0.0002835712,0.0002908641,0.0001229911,0.0002587405,0.001709077],"category_scores_gemma":[0.0001269426,0.0001072474,0.0003368952,0.0002666652,0.0001864514,0.00007142549,0.0001835714,0.0004026021,0.000490783],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004327247,"about_ca_system_score_gemma":0.0002833693,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001949486,"about_ca_topic_score_gemma":0.003907653,"domain_scores_codex":[0.9999045,0.00001026533,0.000008450491,0.00002372762,0.00002797848,0.00002504344],"domain_scores_gemma":[0.9999365,0.00001141063,0.00001679119,0.00000737931,0.00001158484,0.00001631847],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003236019,0.00002605356,0.00293095,0.00008271896,0.00001506279,0.0001415355,0.00003239484,0.0001125981,0.9921942,0.00008416425,0.0003478884,0.003708849],"study_design_scores_gemma":[0.00008244721,0.0003400849,0.08950216,0.00001857669,0.00007067758,0.00105692,0.0002056718,0.002639072,0.8918396,0.0001925644,0.01403213,0.0000201542],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9871497,0.005155392,0.002324644,0.0002766381,0.00006656875,0.00003245577,0.002835232,0.0001716295,0.001987725],"genre_scores_gemma":[0.9934375,0.00107655,0.001111523,0.0001407822,0.000007685071,0.0000345121,0.002074451,0.00002078211,0.002096252],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001949486,"threshold_uncertainty_score":0.005717397,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02174295086396704,"score_gpt":0.2624104619659878,"score_spread":0.2406675111020208,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}