{"id":"W4405234352","doi":"10.26508/lsa.202402912","title":"Mitochondrial signatures shape phenotype switching and apoptosis in response to PLK1 inhibitors","year":2024,"lang":"en","type":"article","venue":"Life Science Alliance","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Natural Sciences and Engineering Research Council of Canada; Hospital for Sick Children; Cancer Research Society","keywords":"PLK1; Gene silencing; Phenotype; Cancer research; Apoptosis; Biology; Gene; Genetics; Cell cycle","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007033845,0.0001742882,0.000221454,0.0003528542,0.0001168167,0.0001684478,0.0002248335,0.0001052063,0.00003475133],"category_scores_gemma":[0.001543296,0.0001590739,0.00004856857,0.002071945,0.0001988897,0.0002932385,0.000130942,0.000445451,0.00008636547],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002209118,"about_ca_system_score_gemma":0.0008393581,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004856559,"about_ca_topic_score_gemma":0.00002934478,"domain_scores_codex":[0.9978516,0.0000456985,0.0002642442,0.000757749,0.0006211043,0.0004596743],"domain_scores_gemma":[0.9990632,0.0001318179,0.00003204993,0.0003157077,0.00006342742,0.0003938258],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007437324,0.00002351247,0.0002457911,0.00005144902,0.000008286946,0.00005906649,0.001513217,0.0002393818,0.9877387,0.0001807461,0.001280571,0.00791558],"study_design_scores_gemma":[0.006702761,0.003035368,0.07766396,0.01221595,0.0002205226,0.0001753707,0.001713709,0.06137915,0.7157633,0.001212805,0.1173975,0.00251963],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9870122,0.003508166,0.0003252589,0.006527016,0.001678743,0.0004992416,0.000004522479,0.0001169953,0.0003278208],"genre_scores_gemma":[0.994234,0.00008301344,0.003243743,0.001848874,0.0003564168,0.00003359551,9.117853e-7,0.00002567775,0.0001737847],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2719754,"threshold_uncertainty_score":0.6486846,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01315629365197405,"score_gpt":0.2834234514943065,"score_spread":0.2702671578423325,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}