{"id":"W4405234352","doi":"10.26508/lsa.202402912","title":"Mitochondrial signatures shape phenotype switching and apoptosis in response to PLK1 inhibitors","year":2024,"lang":"en","type":"article","venue":"Life Science Alliance","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Natural Sciences and Engineering Research Council of Canada; Hospital for Sick Children; Cancer Research Society","keywords":"PLK1; Gene silencing; Phenotype; Cancer research; Apoptosis; Biology; Gene; Genetics; Cell cycle","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001045781,0.0001180179,0.0001978238,0.0002448292,0.0001278952,0.0004467121,0.00008022001,0.0002302737,0.001488015],"category_scores_gemma":[0.0002205037,0.0001052865,0.0001547704,0.0001686944,0.0001501734,0.0002782333,0.0002033,0.000440335,0.0003808195],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003025716,"about_ca_system_score_gemma":0.0001139438,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000246756,"about_ca_topic_score_gemma":0.000344058,"domain_scores_codex":[0.9998684,0.00002042903,0.000009814509,0.00002540534,0.00004192397,0.00003396959],"domain_scores_gemma":[0.9998543,0.00001926857,0.0000621423,0.00001255545,0.0000223266,0.00002938848],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006297557,0.00004517132,0.001904356,0.00003717754,0.000009846325,0.0000680116,0.00004553155,0.0002181179,0.9918269,0.0002005462,0.0001822013,0.004832464],"study_design_scores_gemma":[0.00006446847,0.000877161,0.1021515,0.00001645067,0.00002334081,0.0008663404,0.0002473487,0.00240283,0.8867208,0.0004666025,0.006147837,0.0000153679],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941885,0.001634518,0.001499101,0.0001900565,0.00002130545,0.00002477205,0.0004612595,0.00007504112,0.001905334],"genre_scores_gemma":[0.9977432,0.0005653035,0.0003913104,0.00005934665,0.000004632272,0.00001662689,0.0002265634,0.000009452348,0.0009834621],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001488015,"threshold_uncertainty_score":0.004977882,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01315629365197405,"score_gpt":0.2834234514943065,"score_spread":0.2702671578423325,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}