{"id":"W4405241711","doi":"10.3390/ph17121662","title":"The Small GTPase Ran Increases Sensitivity of Ovarian Cancer Cells to Oncolytic Vesicular Stomatitis Virus","year":2024,"lang":"en","type":"article","venue":"Pharmaceuticals","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; McGill University; Centre Hospitalier de l’Université de Montréal","funders":"Fonds de Recherche du Québec - Santé; Institute of Cancer Research; Institut Du Cancer de Montréal; Mitacs; Canadian Institutes of Health Research; Ovarian Cancer Canada; Fondation du cancer du sein du Québec","keywords":"Ran; Vesicular stomatitis virus; Oncolytic virus; Ovarian cancer; Small interfering RNA; Cancer; Cancer research; Small GTPase; Medicine; Vesicular Stomatitis; Biology; Virus; Virology; Internal medicine; Cell culture; Signal transduction; Cell biology; Transfection; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001591466,0.0002245651,0.0002387142,0.0002272268,0.0001335265,0.0002891413,0.0001276812,0.0002442827,0.001368609],"category_scores_gemma":[0.0002079642,0.00009357843,0.0003150958,0.0001754549,0.0001675278,0.000159767,0.000204464,0.0005760998,0.0002515249],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002761013,"about_ca_system_score_gemma":0.0001820579,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007819415,"about_ca_topic_score_gemma":0.0007708718,"domain_scores_codex":[0.9998046,0.00003784406,0.00002377619,0.00003369383,0.00005924006,0.00004092356],"domain_scores_gemma":[0.9998547,0.00005626113,0.00002855336,0.00001884941,0.00002427011,0.00001730145],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001745742,0.00006896549,0.0006028241,0.00006500598,0.00001108167,0.00003376769,0.00002697685,0.0001643114,0.9968342,0.00006834219,0.00008329329,0.001866632],"study_design_scores_gemma":[0.00001247015,0.0005231492,0.004825266,0.000006936048,0.00001582524,0.0001427783,0.00003359215,0.001249328,0.9912127,0.00002548948,0.001948479,0.000003973681],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941722,0.002169898,0.001629039,0.00009047162,0.00004391563,0.00003751237,0.0003447865,0.00007746245,0.001434579],"genre_scores_gemma":[0.9962087,0.0007228247,0.001308447,0.00004235368,0.000007564886,0.0000397114,0.0005938362,0.00001588836,0.001060693],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001368609,"threshold_uncertainty_score":0.004578471,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03912314590346001,"score_gpt":0.3763844626175316,"score_spread":0.3372613167140716,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}