{"id":"W4405248118","doi":"10.1002/cpt.3512","title":"Mapping the Clinical Development Trajectory of Cell and Gene Therapy Products","year":2024,"lang":"en","type":"article","venue":"Clinical Pharmacology & Therapeutics","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute","keywords":"Medicine; Chimeric antigen receptor; Clinical trial; Internal medicine; Oncology; Immunotherapy","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01088401,0.0003933485,0.0003914172,0.002248981,0.0003320939,0.001718448,0.0004518588,0.0005346952,0.003026324],"category_scores_gemma":[0.02974011,0.0003324312,0.001043021,0.001441865,0.0006774396,0.001295592,0.001272776,0.0008592797,0.0007664136],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007688338,"about_ca_system_score_gemma":0.0008874485,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001490478,"about_ca_topic_score_gemma":0.001230776,"domain_scores_codex":[0.9949834,0.001988109,0.0006084534,0.001026624,0.0009421341,0.0004511752],"domain_scores_gemma":[0.9457866,0.02739939,0.02084082,0.001995825,0.002519287,0.001458037],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007365062,0.00006113913,0.9724857,0.00005923372,0.0001706946,0.0001533829,0.000158209,0.005872156,0.000990485,0.0005126415,0.0002050115,0.01859491],"study_design_scores_gemma":[0.00006301029,0.001356488,0.9631171,0.00006133444,0.000308228,0.001636984,0.0004927278,0.02373595,0.003541562,0.001564254,0.004074401,0.00004800047],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914809,0.001057697,0.004474392,0.0001118758,0.000004479679,0.0001024162,0.001000827,0.00004043941,0.001726976],"genre_scores_gemma":[0.9971778,0.0003301933,0.001226368,0.00002274226,0.000004882151,0.00004988083,0.0008637024,0.00001404275,0.0003103983],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01088401,"threshold_uncertainty_score":0.05756086,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2873189533852471,"score_gpt":0.4787642868699958,"score_spread":0.1914453334847487,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}