{"id":"W4405248223","doi":"10.1101/2024.12.06.626451","title":"Chemical perturbations impacting histone acetylation govern colorectal cancer differentiation","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Cancer Institute; Harvard Digestive Diseases Center, Harvard University; National Institutes of Health; Incyte; Genentech; U.S. Department of Defense; Colorectal Cancer Alliance; Dana-Farber/Harvard Cancer Center; AstraZeneca; Eli Lilly and Company; Bristol-Myers Squibb; Servier; Amgen","keywords":"Epigenetics; Biology; HDAC1; Histone deacetylase 2; Histone deacetylase; Acetylation; Cancer research; Histone; Histone deacetylase 5; HDAC11; Cellular differentiation; Cancer epigenetics; Histone methyltransferase; Cell biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009509355,0.0002021424,0.0001456956,0.0001191876,0.0001145338,0.0002213151,0.000133832,0.0001920679,0.001281611],"category_scores_gemma":[0.00008691214,0.0001636441,0.0001569264,0.0001216389,0.0001681184,0.0001019578,0.0001255157,0.0003228989,0.0004340289],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003354371,"about_ca_system_score_gemma":0.0001767701,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007769761,"about_ca_topic_score_gemma":0.001843679,"domain_scores_codex":[0.9999263,0.0000070401,0.000004000082,0.00001598723,0.00002735847,0.0000192088],"domain_scores_gemma":[0.9999704,0.000005871308,0.000009746652,0.000004163841,0.000003594406,0.00000619948],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003621823,0.000005980504,0.00009831721,0.00001349058,0.000002220363,0.00001054005,0.0000024206,0.00007556804,0.9989121,0.00007295424,0.00003066008,0.0007396067],"study_design_scores_gemma":[0.000004440894,0.00004957936,0.000882213,8.988807e-7,0.000004012308,0.00003252632,0.000003277194,0.0004954979,0.9975234,0.00002892247,0.0009738847,0.000001450608],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9841377,0.001901935,0.006424198,0.0001514324,0.00005809352,0.0000497363,0.000976139,0.0002132102,0.006087589],"genre_scores_gemma":[0.9902975,0.001236024,0.003388925,0.00005648983,0.000007340322,0.00002197202,0.0005690871,0.000038943,0.004383619],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001281611,"threshold_uncertainty_score":0.004287422,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01094634534257043,"score_gpt":0.26882827844874,"score_spread":0.2578819331061696,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}