{"id":"W4405248716","doi":"10.1038/s41551-024-01273-9","title":"Heterogeneity-driven phenotypic plasticity and treatment response in branched-organoid models of pancreatic ductal adenocarcinoma","year":2024,"lang":"en","type":"article","venue":"Nature Biomedical Engineering","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"European Association for the Study of the Liver; Deutsche Krebshilfe; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Klaus Tschira Stiftung; Technische Universität München; Bundesministerium für Bildung und Forschung; Deutsche Forschungsgemeinschaft; Deutschen Konsortium für Translationale Krebsforschung; Deutscher Akademischer Austauschdienst","keywords":"Organoid; Pancreatic ductal adenocarcinoma; Phenotype; Biology; Adenocarcinoma; Phenotypic plasticity; Pancreatic cancer; Cancer research; Cancer; Cell biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00016396,0.000167493,0.0001762016,0.0002270477,0.0001275598,0.0003349859,0.0001280192,0.0002235481,0.0006422284],"category_scores_gemma":[0.0001487732,0.000102364,0.0001692052,0.0001541625,0.0001982243,0.0002022816,0.000265792,0.0005980728,0.0001254375],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002872482,"about_ca_system_score_gemma":0.0001883641,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007334977,"about_ca_topic_score_gemma":0.001121138,"domain_scores_codex":[0.9998566,0.00003145192,0.000011636,0.00003359925,0.00004378183,0.00002290027],"domain_scores_gemma":[0.9998074,0.00004154479,0.00005127871,0.00002931701,0.00001602142,0.00005451651],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002146407,0.00005727223,0.0007972651,0.0000395289,0.000008686106,0.00008544849,0.00007929115,0.001973586,0.994389,0.0002243177,0.00007169449,0.002059307],"study_design_scores_gemma":[0.00003160002,0.0008669821,0.01140419,0.00001547408,0.0000315359,0.000417816,0.0001937605,0.008505745,0.9735666,0.0002401371,0.004709429,0.00001675942],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9886044,0.0006428423,0.008632073,0.00007719873,0.0000237696,0.00004194621,0.0004096701,0.0000750172,0.001493001],"genre_scores_gemma":[0.9958691,0.0002699398,0.002367993,0.00002321168,0.000002187069,0.0000488457,0.0002376377,0.0000145555,0.001166593],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007334977,"threshold_uncertainty_score":0.002148509,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01641101239474014,"score_gpt":0.2946975141842508,"score_spread":0.2782865017895106,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}