{"id":"W4405264758","doi":"10.1093/lifemedi/lnae043","title":"DDO1002, an NRF2–KEAP1 inhibitor, improves hematopoietic stem cell aging and stress response","year":2024,"lang":"en","type":"article","venue":"Life Medicine","topic":"Genomics, phytochemicals, and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Aging","funders":"National Key Research and Development Program of China; Natural Science Foundation of Zhejiang Province; Hangzhou Normal University; National Natural Science Foundation of China","keywords":"Haematopoiesis; Stem cell; KEAP1; Fight-or-flight response; Cell biology; Biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008910208,0.0003980738,0.0003138512,0.0004218137,0.0001006327,0.0001581396,0.0001682047,0.000283826,0.001129275],"category_scores_gemma":[0.00006094605,0.0001074738,0.0002175898,0.0001870288,0.0001375552,0.000197274,0.0001515297,0.0005576034,0.0001668797],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000164833,"about_ca_system_score_gemma":0.0001959805,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000360236,"about_ca_topic_score_gemma":0.0008611112,"domain_scores_codex":[0.9999508,0.000007367954,0.00000487045,0.00001082529,0.00001515585,0.00001103863],"domain_scores_gemma":[0.9999732,0.000002517922,0.000007873621,0.000002821396,0.000005449141,0.000008171803],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005262756,0.0002985414,0.0002344478,0.000193682,0.00002294441,0.0000635738,0.00001141198,0.0002182861,0.982419,0.0001505621,0.0002751331,0.01558616],"study_design_scores_gemma":[0.0001192161,0.001479839,0.005075812,0.00001756795,0.00006361723,0.0002944912,0.00002241276,0.001187696,0.9796928,0.0001820015,0.01185335,0.00001103919],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9752955,0.01180878,0.007757152,0.0003981478,0.0001274492,0.00008414052,0.0006822194,0.0003716198,0.00347499],"genre_scores_gemma":[0.9855989,0.005203954,0.003120606,0.0002180297,0.00001841614,0.00005714346,0.0008422723,0.00002317262,0.004917382],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001129275,"threshold_uncertainty_score":0.003777802,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009988876877998272,"score_gpt":0.2566323008977516,"score_spread":0.2466434240197534,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}