{"id":"W4405264758","doi":"10.1093/lifemedi/lnae043","title":"DDO1002, an NRF2–KEAP1 inhibitor, improves hematopoietic stem cell aging and stress response","year":2024,"lang":"en","type":"article","venue":"Life Medicine","topic":"Genomics, phytochemicals, and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Aging","funders":"National Key Research and Development Program of China; Natural Science Foundation of Zhejiang Province; Hangzhou Normal University; National Natural Science Foundation of China","keywords":"Haematopoiesis; Stem cell; KEAP1; Fight-or-flight response; Cell biology; Biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003616684,0.0002418293,0.0002560516,0.00007844314,0.00007244689,0.00004346659,0.0001749831,0.0001413033,0.00002237579],"category_scores_gemma":[0.00008431061,0.0001992158,0.00004855885,0.00009089542,0.0002519253,0.000009135272,0.0001390127,0.0001718741,0.000008871406],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001431011,"about_ca_system_score_gemma":0.00008364746,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001702092,"about_ca_topic_score_gemma":0.000007203024,"domain_scores_codex":[0.998558,0.0001161615,0.0002946217,0.0005750493,0.0001623585,0.0002938301],"domain_scores_gemma":[0.9991267,0.00006842231,0.00005935131,0.0003964601,0.0000622482,0.0002867891],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001946497,0.00003909921,0.0006282695,0.0002730619,0.00003562096,0.00002037288,0.001035891,0.000002206103,0.9924788,0.00003883071,0.003406822,0.001846363],"study_design_scores_gemma":[0.0008847765,0.0007625577,0.001270505,0.0002859206,0.0000623299,0.00001977302,0.002549786,0.0001313883,0.9741456,0.0001940783,0.01936111,0.0003321576],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9793677,0.01761202,0.0003594443,0.001517958,0.0004516475,0.0001835357,0.00004666923,0.0000438499,0.0004171913],"genre_scores_gemma":[0.9958002,0.0004635992,0.0001307304,0.0007338961,0.001294396,0.00001820789,0.0001053811,0.00004320571,0.001410377],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01833319,"threshold_uncertainty_score":0.8123785,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009988876877998272,"score_gpt":0.2566323008977516,"score_spread":0.2466434240197534,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}