{"id":"W4405273033","doi":"10.1210/endrev/bnae031","title":"The Biology and Clinical Implications of PCSK7","year":2024,"lang":"en","type":"review","venue":"Endocrine Reviews","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Clinical Research Institute","funders":"Canadian Institutes of Health Research","keywords":"PCSK9; Biology; Disease; Bioinformatics; Proprotein convertase; Kexin; Population; Medicine; Computational biology; LDL receptor; Lipoprotein; Internal medicine; Cholesterol; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005774684,0.0003522848,0.0004648017,0.0007723542,0.0002345206,0.0009915645,0.0002943411,0.0009711527,0.002221585],"category_scores_gemma":[0.001147392,0.0001463704,0.0003836702,0.0004260961,0.0009271071,0.0007262868,0.0005370734,0.002430919,0.001338248],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000578627,"about_ca_system_score_gemma":0.0008764659,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000578651,"about_ca_topic_score_gemma":0.0004528525,"domain_scores_codex":[0.9997299,0.00005200953,0.00004286878,0.00004748433,0.00009511445,0.00003256281],"domain_scores_gemma":[0.9995955,0.0001711344,0.00004458468,0.00002078524,0.0001103717,0.00005771459],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0007047275,0.00009301714,0.002587573,0.004800819,0.0001119558,0.002634165,0.0003043621,0.0005378678,0.02903601,0.03641475,0.06618086,0.856594],"study_design_scores_gemma":[0.00005117228,0.0002564257,0.002855463,0.001123016,0.00008956467,0.009960756,0.0001364061,0.0002247089,0.009329818,0.01047764,0.9654596,0.00003545405],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.003377321,0.9754033,0.001331004,0.01146603,0.002077064,0.000009862925,0.0001010387,0.00003864575,0.006195707],"genre_scores_gemma":[0.03810772,0.9404976,0.001549781,0.007000771,0.00735111,0.00003503526,0.0002421002,0.00002854465,0.005187364],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002221585,"threshold_uncertainty_score":0.007431924,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1440210328403449,"score_gpt":0.5091755854199085,"score_spread":0.3651545525795635,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}