{"id":"W4405273033","doi":"10.1210/endrev/bnae031","title":"The Biology and Clinical Implications of PCSK7","year":2024,"lang":"en","type":"review","venue":"Endocrine Reviews","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Clinical Research Institute","funders":"Canadian Institutes of Health Research","keywords":"PCSK9; Biology; Disease; Bioinformatics; Proprotein convertase; Kexin; Population; Medicine; Computational biology; LDL receptor; Lipoprotein; Internal medicine; Cholesterol; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001822719,0.0002629538,0.003207149,0.0000653039,0.00006121093,0.00001170203,0.0001633348,0.0001130775,0.00001575737],"category_scores_gemma":[0.0005476057,0.0001147129,0.00197549,0.0002880075,0.0001678559,0.000009726557,0.0001553653,0.000584803,0.0001617665],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003266112,"about_ca_system_score_gemma":0.0002983786,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003098637,"about_ca_topic_score_gemma":0.00001015273,"domain_scores_codex":[0.9971488,0.000548136,0.001593471,0.0003896023,0.00009250588,0.0002275116],"domain_scores_gemma":[0.9979787,0.0002506196,0.0003608808,0.001222927,0.00004973025,0.0001370918],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[9.230757e-7,0.00001652585,0.000008217446,0.03061314,0.0003518723,0.000003462918,0.00000116318,1.048615e-10,2.581895e-8,0.004039028,0.005741234,0.9592244],"study_design_scores_gemma":[0.0001039709,0.0001037167,0.00001978462,0.01020726,0.004930669,0.0006129939,0.000001022966,1.084444e-7,4.844925e-8,0.0001950197,0.9837377,0.00008770965],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[3.07147e-7,0.9937106,0.00002033719,0.001331925,0.0003028607,0.002702274,0.00002647495,0.000022136,0.00188308],"genre_scores_gemma":[9.027134e-7,0.9973668,0.0002373775,0.00007718063,0.0009058636,0.0004110605,0.00005956749,0.00003545075,0.0009057488],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9779965,"threshold_uncertainty_score":0.4677857,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1440210328403449,"score_gpt":0.5091755854199085,"score_spread":0.3651545525795635,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}