{"id":"W4405275475","doi":"10.2139/ssrn.5044690","title":"A New Class of Brca1 Mimetics for Erα Positive Breast Cancer Therapy: Design, Synthesis, in Silico Screening, in Vitro Assay and Gene Expression Analysis","year":2024,"lang":"en","type":"preprint","venue":"SSRN Electronic Journal","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan","funders":"","keywords":"In silico; In vitro; Breast cancer; Cancer research; Computational biology; Gene; Chemistry; Cancer; Biology; Medicine; Internal medicine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003473932,0.0006202175,0.0007872863,0.0003515678,0.0001717783,0.0003946119,0.000467847,0.0004600583,0.002501169],"category_scores_gemma":[0.0002400068,0.0002035628,0.0004611537,0.0002924853,0.0001479447,0.0002179156,0.0002181645,0.0007551094,0.001041253],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003884518,"about_ca_system_score_gemma":0.0002573794,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001821937,"about_ca_topic_score_gemma":0.000430118,"domain_scores_codex":[0.9998811,0.00002324965,0.000007167513,0.00003529865,0.00003939825,0.00001362489],"domain_scores_gemma":[0.9999344,0.00001721985,0.0000167423,0.000007763777,0.000008780916,0.00001501768],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006153643,0.0001967331,0.0002371672,0.0003839758,0.00004924095,0.0002377576,0.00003454669,0.002847957,0.9578831,0.0008031921,0.001106578,0.03560444],"study_design_scores_gemma":[0.0003647638,0.003099669,0.001124255,0.00003808742,0.0001617432,0.001196971,0.00002516606,0.005049044,0.944034,0.000478017,0.0443855,0.00004279969],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.867062,0.02805855,0.08115862,0.0009656547,0.0003768094,0.001208439,0.006019977,0.001803121,0.01334684],"genre_scores_gemma":[0.8507362,0.01603965,0.1082372,0.0007358221,0.00009153931,0.001150049,0.005702235,0.0002526725,0.01705464],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002501169,"threshold_uncertainty_score":0.00836724,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007301071248503021,"score_gpt":0.2600829358376949,"score_spread":0.2527818645891919,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}