{"id":"W4405280661","doi":"10.1126/scitranslmed.ado7824","title":"ATP citrate lyase drives vascular remodeling in systemic and pulmonary vascular diseases through metabolic and epigenetic changes","year":2024,"lang":"en","type":"article","venue":"Science Translational Medicine","topic":"Pulmonary Hypertension Research and Treatments","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Heart Research Centre","funders":"","keywords":"Vascular smooth muscle; ATP citrate lyase; Pulmonary artery; Medicine; Pulmonary hypertension; Glycolysis; Acetylation; Cancer research; Endocrinology; Internal medicine; Biology; Pharmacology; Biochemistry; Enzyme; Citrate synthase; Metabolism","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005463841,0.0001898843,0.0003774135,0.0004646385,0.0001667597,0.00003198864,0.00009080578,0.00004014647,0.00004109616],"category_scores_gemma":[0.0001053975,0.000128385,0.00004723184,0.0009130853,0.0009151435,0.0003071807,0.00002712012,0.0001556656,0.000005404892],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002560714,"about_ca_system_score_gemma":0.0002633434,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000115118,"about_ca_topic_score_gemma":0.00001086917,"domain_scores_codex":[0.9977573,0.00005727507,0.0002493745,0.0006141062,0.0009558657,0.0003660966],"domain_scores_gemma":[0.9991903,0.0001465381,0.00002032057,0.0001996487,0.0001018257,0.0003413167],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0006342495,0.0009894338,0.264614,0.004566089,0.0008936853,0.01215007,0.008386753,0.0007610277,0.4644361,0.01051308,0.00006123853,0.2319943],"study_design_scores_gemma":[0.003096588,0.0004435219,0.853821,0.004287113,0.0007073751,0.001460828,0.0009403288,0.124187,0.0005108915,0.007723843,0.002446546,0.0003750241],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7323238,0.2591057,0.0003694378,0.007360087,0.0001066364,0.0005015478,0.00002018357,0.00004813829,0.0001644762],"genre_scores_gemma":[0.9777042,0.0211747,0.0005781179,0.0002723058,0.000133262,0.00003917958,0.00003883933,0.0000156724,0.00004374906],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.589207,"threshold_uncertainty_score":0.5235389,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03328429558210709,"score_gpt":0.3169229562706525,"score_spread":0.2836386606885454,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}