{"id":"W4405280868","doi":"10.1213/ane.0000000000007349","title":"The Influence of Pharmacogenetic Factors on the Pharmacokinetics of Morphine and Its Metabolites in Pediatric Patients: A Systematic Review","year":2024,"lang":"en","type":"review","venue":"Anesthesia & Analgesia","topic":"Pharmaceutical studies and practices","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Medicine; Pharmacogenetics; Morphine; Pharmacokinetics; Analgesic; Dosing; MEDLINE; Pharmacology; Adverse effect; Meta-analysis; Pharmacogenomics; Bioinformatics; Internal medicine; Genotype; Genetics; Biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001133006,0.0005028349,0.002647031,0.000171291,0.0000744025,0.00002169223,0.0003893749,0.00009622526,0.00001987356],"category_scores_gemma":[0.0008124947,0.0002089142,0.0004303455,0.001158954,0.0001148879,0.00004852817,0.00008414651,0.0005941726,0.00001869092],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003334985,"about_ca_system_score_gemma":0.0001018476,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008452775,"about_ca_topic_score_gemma":6.913949e-7,"domain_scores_codex":[0.9966019,0.0006851638,0.00149119,0.0003401901,0.0005860563,0.0002955354],"domain_scores_gemma":[0.9957824,0.002550089,0.0009808249,0.0003782121,0.00019524,0.0001131939],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"systematic_review","study_design_scores_codex":[0.00002277599,0.0001476411,0.0004871257,0.9933928,0.0007750344,0.0000496855,0.0000574373,7.802255e-7,0.000001776334,0.0001728891,0.0004364482,0.004455632],"study_design_scores_gemma":[0.000620904,0.0004407437,0.003153418,0.5527704,0.1137966,0.0001428524,0.00004407177,0.0000434367,0.00003721425,0.00003033481,0.3283221,0.0005978722],"study_design_candidate":"systematic_review","study_design_consensus":"systematic_review","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.02027811,0.9754969,3.084623e-8,0.0009648776,0.00002797171,0.00317225,0.00001418795,0.00001165054,0.00003400422],"genre_scores_gemma":[0.01724906,0.9817547,0.000001997393,0.000652722,0.00004792367,0.0002054385,0.000009800785,0.00004242586,0.00003594826],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.4406223,"threshold_uncertainty_score":0.8519275,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05554630450023756,"score_gpt":0.3739935989629722,"score_spread":0.3184472944627346,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}