{"id":"W4405288250","doi":"10.1016/j.xgen.2024.100721","title":"Effects of gene dosage on cognitive ability: A function-based association study across brain and non-brain processes","year":2024,"lang":"en","type":"article","venue":"Cell Genomics","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; HEC Montréal; Hospital for Sick Children; Mila - Quebec Artificial Intelligence Institute; Centre Hospitalier Universitaire Sainte-Justine","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute on Drug Abuse; National Institute of Mental Health; National Institute for Health and Care Research; National Institute on Aging; Economic and Social Research Council; National Center for Mental Health; Wellcome Trust; Biotechnology and Biological Sciences Research Council; Medical Research Council; Scottish Government; Chief Scientist Office, Scottish Government Health and Social Care Directorate; Directorate for Biological Sciences; National Institutes of Health; Health and Care Research Wales; Deutsche Forschungsgemeinschaft; Bundesministerium für Bildung und Forschung; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; Compute Canada; Age UK; Scottish Funding Council; King's College London; Agence Nationale de la Recherche; Fondation Brain Canada; South London and Maudsley NHS Foundation Trust; Heart and Stroke Foundation of Canada","keywords":"Brain function; Association (psychology); Cognition; Neuroscience; Psychology; Medicine; Psychotherapist","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001987561,0.0001387802,0.0001186028,0.00002984679,0.00006260112,0.00004075274,0.00006093775,0.00008900644,0.000002288014],"category_scores_gemma":[0.0001816438,0.0001403421,0.0000392527,0.000106013,0.00003285278,0.000002029243,0.00004523587,0.0000674348,0.000005202506],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002805151,"about_ca_system_score_gemma":0.0001430698,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006680818,"about_ca_topic_score_gemma":0.00003098425,"domain_scores_codex":[0.9991629,0.00004701153,0.000151682,0.0003756067,0.00009896756,0.0001638463],"domain_scores_gemma":[0.9995313,0.0002024386,0.00005882307,0.00009885601,0.00006608184,0.00004250558],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001309694,0.0003125576,0.006999835,0.0004936308,0.0000736309,0.000003423846,0.0007349161,0.0000792076,0.9892435,3.039258e-7,0.0002871855,0.001640856],"study_design_scores_gemma":[0.001353863,0.001489567,0.08860146,0.00003416165,0.00005359795,3.982544e-7,0.0006049058,0.0001276654,0.9063212,0.00002414056,0.001180829,0.0002081848],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973765,0.0009421757,0.0007093907,0.00008129084,0.0001410354,0.0005703853,0.00005154617,0.000009121577,0.0001185331],"genre_scores_gemma":[0.9989115,0.00008867258,0.00006043917,0.0004812397,0.00002439011,0.00004932108,0.00007538782,0.00002549049,0.0002835556],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08292225,"threshold_uncertainty_score":0.5722985,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003899412071569251,"score_gpt":0.2254252178657647,"score_spread":0.2215258057941955,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}