{"id":"W4405296624","doi":"10.1093/humrep/deae268","title":"Sphingolipids modulate redox signalling during human sperm capacitation","year":2024,"lang":"en","type":"article","venue":"Human Reproduction","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"Canadian Institutes of Health Research; McGill University Health Centre","keywords":"Capacitation; Sperm; Biology; Acrosome reaction; Andrology; Cell biology; Sphingolipid; Percoll; Nitric oxide; Sphingosine; Immunology; Motility; Biochemistry; Endocrinology; Receptor; Medicine; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005110151,0.0002025994,0.0001568506,0.0001558515,0.0004025796,0.0001468184,0.0001277533,0.0001339783,0.00005644382],"category_scores_gemma":[0.00006063755,0.0002139284,0.0001324256,0.0001750716,0.00006527848,0.00002173225,0.00005449899,0.0001868491,0.00002824528],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003379962,"about_ca_system_score_gemma":0.00002260736,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005199175,"about_ca_topic_score_gemma":0.00001306042,"domain_scores_codex":[0.9982114,0.00005736979,0.0003331519,0.0009226464,0.0001970718,0.0002783268],"domain_scores_gemma":[0.9992514,0.000003562324,0.00007274523,0.0005186636,0.00008798992,0.00006568398],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001689107,0.00002235293,0.0001380408,0.0001492985,0.00005024911,0.000005853085,0.0004703994,0.002134853,0.9951115,0.001090201,0.0002133115,0.0005970614],"study_design_scores_gemma":[0.0002902501,0.00007770231,0.003334255,0.00008772228,0.0000535841,0.00006121051,0.0001447127,0.0002924599,0.9849965,0.001128124,0.009199739,0.0003337553],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947051,0.002074973,0.000848554,0.00006109582,0.001147226,0.0001864264,0.00000348636,0.000162693,0.000810432],"genre_scores_gemma":[0.9892101,0.00008473698,0.0002703113,0.0000215061,0.006815205,0.00002225288,0.0001781902,0.00006027207,0.003337391],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.010115,"threshold_uncertainty_score":0.8723748,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01679552888957769,"score_gpt":0.272747237542762,"score_spread":0.2559517086531843,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}