{"id":"W4405296624","doi":"10.1093/humrep/deae268","title":"Sphingolipids modulate redox signalling during human sperm capacitation","year":2024,"lang":"en","type":"article","venue":"Human Reproduction","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"Canadian Institutes of Health Research; McGill University Health Centre","keywords":"Capacitation; Sperm; Biology; Acrosome reaction; Andrology; Cell biology; Sphingolipid; Percoll; Nitric oxide; Sphingosine; Immunology; Motility; Biochemistry; Endocrinology; Receptor; Medicine; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000361389,0.0002100541,0.0002755315,0.0002236832,0.0001449226,0.0004027034,0.0002203081,0.0004193982,0.002413244],"category_scores_gemma":[0.0003354991,0.0001199101,0.0002413964,0.0001710223,0.0001718274,0.0003370718,0.000313262,0.000264472,0.0005390063],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002391805,"about_ca_system_score_gemma":0.0002120966,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005079582,"about_ca_topic_score_gemma":0.0005692336,"domain_scores_codex":[0.9998976,0.0000427813,0.000006157261,0.00001494815,0.00001612877,0.00002231779],"domain_scores_gemma":[0.9999049,0.00002209348,0.0000290173,0.000005513744,0.00001938916,0.00001911171],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005956239,0.0001530235,0.02179996,0.0008693472,0.0001075501,0.0007456703,0.0005419869,0.0002652637,0.9353195,0.000652416,0.00107629,0.03251269],"study_design_scores_gemma":[0.0002356724,0.00392024,0.3800399,0.0003657359,0.0004005022,0.002348931,0.001464066,0.002972514,0.5887769,0.001721952,0.01768927,0.00006432882],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.959099,0.03472485,0.001199258,0.001399023,0.0001033246,0.00007258613,0.0004767841,0.00004448703,0.002880623],"genre_scores_gemma":[0.9898931,0.0072192,0.000495742,0.0002447925,0.00007865411,0.00002906305,0.0002638038,0.000006927415,0.001768484],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002413244,"threshold_uncertainty_score":0.008073092,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01679552888957769,"score_gpt":0.272747237542762,"score_spread":0.2559517086531843,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}