{"id":"W4405311054","doi":"10.1016/j.bbi.2024.12.003","title":"Early-life gut inflammation drives sex-dependent shifts in the microbiome-endocrine-brain axis","year":2024,"lang":"en","type":"article","venue":"Brain Behavior and Immunity","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver Coastal Health; Canadian Institute for Advanced Research; University of British Columbia","funders":"Canadian Institutes of Health Research; Johnson and Johnson; Canada Excellence Research Chairs, Government of Canada; Crohn's and Colitis Canada; University of British Columbia; Paul G. Allen Frontiers Group; Natural Sciences and Engineering Research Council of Canada; Fondation Brain Canada; Michael Smith Health Research BC; Research Corporation for Science Advancement","keywords":"Inflammation; Gut–brain axis; Microbiome; Endocrine system; Gut flora; Immunology; Microglia; Disease; Inflammatory bowel disease; Medicine; Systemic inflammation; Hormone; Internal medicine; Biology; Bioinformatics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002046998,0.0004523486,0.0003519806,0.000492375,0.0002129401,0.000520002,0.0002067384,0.0004271595,0.00160491],"category_scores_gemma":[0.0002435173,0.0002291258,0.0003657652,0.0001527423,0.0004218123,0.0002661001,0.0003600341,0.0009707559,0.000266903],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004090778,"about_ca_system_score_gemma":0.0004091844,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007860901,"about_ca_topic_score_gemma":0.002409272,"domain_scores_codex":[0.9997471,0.0000410408,0.00001392987,0.00008069556,0.00005693507,0.00006019395],"domain_scores_gemma":[0.9996707,0.00002884333,0.0001272625,0.00002273381,0.00004344307,0.0001068671],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000952482,0.0001502786,0.008798419,0.00009587068,0.00003403979,0.0002762197,0.0001241657,0.00009844773,0.9817239,0.0003194812,0.0002101665,0.007216465],"study_design_scores_gemma":[0.0000983147,0.003042642,0.3373782,0.00008679669,0.0001767585,0.0009817244,0.0007545425,0.00112329,0.6473551,0.0007214467,0.008217224,0.00006396008],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991015,0.004396466,0.001649612,0.0002635186,0.00007658992,0.0000285001,0.001130805,0.0000857467,0.001353852],"genre_scores_gemma":[0.988378,0.00365357,0.002577276,0.0002519258,0.00003754347,0.0001084356,0.0007593869,0.00004649571,0.004187354],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00160491,"threshold_uncertainty_score":0.005368948,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01313934014200419,"score_gpt":0.2869489205081823,"score_spread":0.2738095803661781,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}