{"id":"W4405311484","doi":"10.1016/j.omtn.2024.102423","title":"Restoring hematopoietic stem and progenitor cell function in Fancc mice by in situ delivery of RNA lipid nanoparticles","year":2024,"lang":"en","type":"article","venue":"Molecular Therapy — Nucleic Acids","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Acuitas Therapeutics (Canada)","funders":"Office of Extramural Research, National Institutes of Health; Children's Hospital of Philadelphia","keywords":"Haematopoiesis; Progenitor cell; Ex vivo; Stem cell; Bone marrow; Gene delivery; Genetic enhancement; Biology; Hematopoietic stem cell; Cell biology; Cancer research; In vivo; Immunology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002988603,0.0006201737,0.0002864706,0.0005451257,0.0002075339,0.0002985442,0.0002691482,0.0005750895,0.00128375],"category_scores_gemma":[0.00010045,0.0002311846,0.0002599682,0.0001682794,0.0004266322,0.0002580925,0.0001428419,0.0007644388,0.0003601451],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003547168,"about_ca_system_score_gemma":0.0002970763,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007148273,"about_ca_topic_score_gemma":0.001088773,"domain_scores_codex":[0.9998178,0.00002939854,0.00001830183,0.00004923028,0.00004871477,0.00003650579],"domain_scores_gemma":[0.9998586,0.00002030677,0.00006289536,0.00001294477,0.000009947371,0.00003528359],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008459276,0.00003695298,0.00004140007,0.0000214112,0.000001881137,0.00002365031,0.00001444882,0.000101745,0.9987533,0.0001846376,0.00003369312,0.0007021864],"study_design_scores_gemma":[0.0000188353,0.0003428805,0.0004341138,0.000005751107,0.000007280154,0.00008358915,0.00001166091,0.0007895855,0.9970405,0.00004511726,0.001217058,0.000003722086],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9839783,0.0008149685,0.011503,0.0002458589,0.00005628728,0.000138211,0.0009608521,0.0004856445,0.001816823],"genre_scores_gemma":[0.9790373,0.00097991,0.01151877,0.0001080993,0.00002035238,0.0002587377,0.0007783276,0.0001216741,0.007176847],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00128375,"threshold_uncertainty_score":0.004294515,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00806716529950856,"score_gpt":0.2185795182347438,"score_spread":0.2105123529352352,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}