{"id":"W4405315272","doi":"10.1016/j.csbj.2024.12.007","title":"Disrupting the network of co-evolving amino terminal domain residues relieves mitochondrial calcium uptake inhibition by MCUb","year":2024,"lang":"en","type":"article","venue":"Computational and Structural Biotechnology Journal","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research","keywords":"Terminal (telecommunication); Calcium; Domain (mathematical analysis); Chemistry; Amino terminal; Biophysics; Biology; Biochemistry; Computer science; Peptide sequence; Computer network; Gene; Mathematics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009311263,0.000254162,0.0003060545,0.0001117672,0.0002345114,0.0002821376,0.0004833561,0.0002441753,0.001438802],"category_scores_gemma":[0.0001339683,0.0001163823,0.0001562625,0.0001080702,0.0002840612,0.0001307642,0.0002899062,0.0004743978,0.0005115269],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003321676,"about_ca_system_score_gemma":0.0002042125,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001418412,"about_ca_topic_score_gemma":0.002027791,"domain_scores_codex":[0.9999115,0.00001447579,0.00001032604,0.00001566535,0.00002594803,0.00002194449],"domain_scores_gemma":[0.9998412,0.00002516223,0.00004496505,0.00001858059,0.00001321848,0.00005683182],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003114083,0.0001217054,0.0002503671,0.00003008719,0.00001262408,0.0001128436,0.00002113346,0.0002301877,0.997243,0.0001581325,0.00007612163,0.001432276],"study_design_scores_gemma":[0.00004165493,0.0001648879,0.003306845,0.000005844763,0.00001646047,0.0001735733,0.00004184749,0.003733447,0.9898366,0.00005347702,0.002616628,0.000008763792],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978272,0.0003347661,0.0009991006,0.00006358206,0.00002625049,0.0000149015,0.0001340136,0.00004369247,0.0005564095],"genre_scores_gemma":[0.9975846,0.0001574316,0.001015603,0.00005206836,0.000009637494,0.00001469558,0.0001895704,0.00004102403,0.0009354611],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001438802,"threshold_uncertainty_score":0.004813254,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009245895581111534,"score_gpt":0.2620965486310679,"score_spread":0.2528506530499564,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}