{"id":"W4405317157","doi":"10.1021/acs.molpharmaceut.4c01071","title":"Preclinical Comparison of [ <sup>111</sup> In]In- and [ <sup>225</sup> Ac]Ac-DOTA-Trastuzumab IgG, F(ab′) <sub>2</sub> and Fab for Theranostic SPECT/CT Imaging and α-Particle Radioimmunotherapy of HER2-Positive Human Breast Cancer","year":2024,"lang":"en","type":"article","venue":"Molecular Pharmaceutics","topic":"Radiopharmaceutical Chemistry and Applications","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; University of Toronto","funders":"Leslie Dan Faculty of Pharmacy, University of Toronto; Canadian Institutes of Health Research; University of Toronto; Pfizer Canada; Terry Fox Foundation; Roche; Pfizer","keywords":"Radioimmunotherapy; DOTA; Nuclear medicine; Trastuzumab; Radiochemistry; Medicine; Medical physics; Chemistry; Monoclonal antibody; Cancer; Chelation; Antibody","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003986311,0.0006327251,0.0004915916,0.0001815834,0.0001409871,0.0003946435,0.0005687355,0.0004295267,0.001292652],"category_scores_gemma":[0.0002228998,0.0003036981,0.000211593,0.0001904208,0.0003546787,0.0003664234,0.0001156692,0.0008201884,0.00031177],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006072958,"about_ca_system_score_gemma":0.0005284499,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002811089,"about_ca_topic_score_gemma":0.002761637,"domain_scores_codex":[0.9998015,0.00005243289,0.00001072693,0.00003163443,0.00004429569,0.00005943024],"domain_scores_gemma":[0.9998031,0.00003465496,0.00004848481,0.00002029956,0.00002604031,0.00006750588],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002552989,0.001070563,0.0004043988,0.00010484,0.00004149711,0.00006041054,0.00004637769,0.001181683,0.9906702,0.000208393,0.0001745402,0.003484105],"study_design_scores_gemma":[0.0001878502,0.01419729,0.00279963,0.000007635634,0.0001219246,0.0002401158,0.0000313481,0.002785818,0.9770697,0.00005560287,0.002493046,0.00001003285],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992067,0.001133682,0.002692178,0.00008673689,0.0000459083,0.0001533451,0.0002692498,0.00008296865,0.003468864],"genre_scores_gemma":[0.9925562,0.0008552651,0.00242016,0.0000497027,0.00001723934,0.00009229009,0.0006907203,0.00004272832,0.003275775],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002811089,"threshold_uncertainty_score":0.005589426,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03050513215193162,"score_gpt":0.3938679972421086,"score_spread":0.363362865090177,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}