{"id":"W4405317157","doi":"10.1021/acs.molpharmaceut.4c01071","title":"Preclinical Comparison of [ <sup>111</sup> In]In- and [ <sup>225</sup> Ac]Ac-DOTA-Trastuzumab IgG, F(ab′) <sub>2</sub> and Fab for Theranostic SPECT/CT Imaging and α-Particle Radioimmunotherapy of HER2-Positive Human Breast Cancer","year":2024,"lang":"en","type":"article","venue":"Molecular Pharmaceutics","topic":"Radiopharmaceutical Chemistry and Applications","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; University of Toronto","funders":"Leslie Dan Faculty of Pharmacy, University of Toronto; Canadian Institutes of Health Research; University of Toronto; Pfizer Canada; Terry Fox Foundation; Roche; Pfizer","keywords":"Radioimmunotherapy; DOTA; Nuclear medicine; Trastuzumab; Radiochemistry; Medicine; Medical physics; Chemistry; Monoclonal antibody; Cancer; Chelation; Antibody","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003803408,0.000325583,0.0006791749,0.0001066603,0.00008359933,0.00004866945,0.0001160747,0.00006366535,0.00002643125],"category_scores_gemma":[0.00003752989,0.0003201748,0.0001217206,0.0003399938,0.0004907014,0.00009988862,0.00006534643,0.0005305383,8.560144e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001053326,"about_ca_system_score_gemma":0.0001027374,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003987684,"about_ca_topic_score_gemma":0.000003337119,"domain_scores_codex":[0.9978752,0.0001071129,0.0007549243,0.0005791875,0.0002571296,0.0004264153],"domain_scores_gemma":[0.9989117,0.0004082927,0.0001089229,0.0002603531,0.00008285305,0.0002278482],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005875888,0.0006439678,0.02393677,0.001004219,0.000313145,0.000121756,0.001450742,0.001300861,0.946253,0.0002434485,0.00005920411,0.02408529],"study_design_scores_gemma":[0.004608291,0.0001561274,0.007336042,0.0005606717,0.0004464304,0.0002562841,0.0004655817,0.2262553,0.7590206,0.0001858235,0.0004381015,0.0002707867],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9726232,0.02404007,0.0005767037,0.001380945,0.00002692149,0.00105497,0.0001811995,0.00003873631,0.00007720271],"genre_scores_gemma":[0.9970688,0.002047084,0.0002264873,0.0003551587,0.00007938768,0.0001175218,0.000028577,0.00006467543,0.00001230263],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2249544,"threshold_uncertainty_score":0.999925,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03050513215193162,"score_gpt":0.3938679972421086,"score_spread":0.363362865090177,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}