{"id":"W4405319343","doi":"10.1158/1078-0432.ccr-24-2523","title":"Sacituzumab Govitecan in Patients with Relapsed/Refractory Advanced Head and Neck Squamous Cell Carcinoma: Results from the Phase II TROPiCS-03 Basket Study","year":2024,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Head and Neck Cancer Studies","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"Gilead Sciences","keywords":"Medicine; Internal medicine; Neutropenia; Mucositis; Adverse effect; Nausea; Phases of clinical research; Head and neck squamous-cell carcinoma; Febrile neutropenia; Surgery; Clinical endpoint; Oncology; Chemotherapy; Gastroenterology; Head and neck cancer; Cancer; Clinical trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001870953,0.0009218024,0.001650302,0.0003079277,0.0002596423,0.0008960514,0.0007079965,0.0006767149,0.001343603],"category_scores_gemma":[0.0008343553,0.0003142045,0.001208781,0.0005489975,0.0005207029,0.0006828181,0.0003108389,0.001493098,0.0004294252],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001040914,"about_ca_system_score_gemma":0.001405087,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00224198,"about_ca_topic_score_gemma":0.006794551,"domain_scores_codex":[0.9996393,0.0001673766,0.00002713265,0.00005174978,0.00005522332,0.00005919932],"domain_scores_gemma":[0.999424,0.00009098868,0.000159412,0.00004229196,0.00005180785,0.0002315306],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5853487,0.03296936,0.08323441,0.001380182,0.004313645,0.0006269022,0.0007316522,0.004750425,0.04738788,0.0002709528,0.01082763,0.2281583],"study_design_scores_gemma":[0.5418862,0.2985256,0.1403265,0.0001517997,0.002564157,0.001080983,0.0002681955,0.003185973,0.004812589,0.0002784536,0.006852996,0.00006650353],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941241,0.003239989,0.0001566545,0.0002375126,0.00003307932,0.0004885606,0.0008390253,0.00003597602,0.0008451089],"genre_scores_gemma":[0.9914052,0.002768276,0.0006330534,0.0006695658,0.0001059492,0.000521091,0.00311598,0.00002289123,0.000757923],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00224198,"threshold_uncertainty_score":0.009894729,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1086492114854232,"score_gpt":0.4598629325768382,"score_spread":0.351213721091415,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}