{"id":"W4405320643","doi":"10.1158/2159-8290.cd-24-0878","title":"Predisposition Footprints in the Somatic Genome of Wilms Tumors","year":2024,"lang":"en","type":"article","venue":"Cancer Discovery","topic":"Renal and related cancers","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"NIHR Great Ormond Street Hospital Biomedical Research Centre; Deutsche Forschungsgemeinschaft; Wenner-Gren Stiftelserna; University of Cambridge; NIHR Cambridge Biomedical Research Centre; Wellcome Trust; National Institute for Health and Care Research; Little Princess Trust; Deutsche Krebshilfe; Wilhelm Sander-Stiftung","keywords":"Somatic cell; Wilms' tumor; Wilms tumour; Genome; Biology; Genetics; Genetic predisposition; Computational biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000989034,0.0002923022,0.0003099505,0.0005135804,0.0006412774,0.0008453472,0.0003913629,0.001450871,0.001491277],"category_scores_gemma":[0.002242439,0.0002348609,0.0002493947,0.0006015197,0.001057266,0.0006211451,0.0007511685,0.002451963,0.0004063795],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006530048,"about_ca_system_score_gemma":0.0005059128,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003625923,"about_ca_topic_score_gemma":0.01329926,"domain_scores_codex":[0.9994181,0.0001125023,0.00003106896,0.0002006708,0.0001771577,0.00006043121],"domain_scores_gemma":[0.9988465,0.0007398992,0.0001012166,0.00005761412,0.0001277466,0.0001269026],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"observational","study_design_scores_codex":[0.001069915,0.00008513835,0.1492696,0.001031097,0.0004432928,0.008555539,0.002747342,0.00142719,0.09835664,0.02054289,0.4434521,0.2730193],"study_design_scores_gemma":[0.0001076427,0.0002734359,0.2952507,0.0006679132,0.0004228418,0.008555349,0.001703906,0.001135169,0.02829275,0.02593646,0.6374742,0.0001796305],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.4297301,0.1290486,0.01278907,0.3727467,0.01926217,0.00009425967,0.006521516,0.001025483,0.028782],"genre_scores_gemma":[0.7232656,0.07045534,0.006016846,0.1398298,0.03033686,0.0001143458,0.002836865,0.0004254205,0.02671893],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003625923,"threshold_uncertainty_score":0.007209659,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00602928684431275,"score_gpt":0.2469512702521758,"score_spread":0.2409219834078631,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}