{"id":"W4405363564","doi":"10.1101/2024.02.23.24302586","title":"Tixagevimab-cilgavimab (AZD7442) for the treatment of patients hospitalized with COVID-19 (DisCoVeRy): A phase 3, randomized, double-blind, placebo-controlled trial","year":2024,"lang":"en","type":"preprint","venue":"medRxiv","topic":"COVID-19 Clinical Research Studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hotel Dieu Hospital","funders":"European Commission","keywords":"Coronavirus disease 2019 (COVID-19); Placebo; Double blind; Randomized controlled trial; Medicine; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); 2019-20 coronavirus outbreak; Phase (matter); Internal medicine; Virology; Alternative medicine; Disease; Pathology; Physics; Outbreak","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003123852,0.001526245,0.002946639,0.0004960042,0.0006550627,0.001494548,0.0009196434,0.002686306,0.005913177],"category_scores_gemma":[0.001890809,0.0005796051,0.002472296,0.0005367607,0.001087902,0.0009376057,0.0003418071,0.002448769,0.0008173282],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006478368,"about_ca_system_score_gemma":0.001797529,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005818282,"about_ca_topic_score_gemma":0.001101431,"domain_scores_codex":[0.9988672,0.0006495194,0.00009465627,0.0001584331,0.00008955212,0.00014069],"domain_scores_gemma":[0.9988981,0.0003651091,0.0002471615,0.00006380874,0.00009327177,0.0003325081],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.979818,0.004386252,0.0004882975,0.001142888,0.0007214753,0.00004466399,0.00003350974,0.0001142061,0.002055568,0.00009293872,0.0008555945,0.01024663],"study_design_scores_gemma":[0.9658002,0.03228071,0.0006890259,0.0000423059,0.000360011,0.0000236565,0.000008515221,0.0001273546,0.0002104991,0.0000565296,0.0003940031,0.000007182033],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9544774,0.02327168,0.001119915,0.001737585,0.001612119,0.01185636,0.002244569,0.0002719522,0.003408471],"genre_scores_gemma":[0.9708533,0.007727195,0.002398737,0.002174502,0.001384963,0.01133066,0.001587581,0.00003049336,0.002512519],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005913177,"threshold_uncertainty_score":0.01978153,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07721824159315836,"score_gpt":0.4436207529348706,"score_spread":0.3664025113417123,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}