{"id":"W4405368113","doi":"10.1158/1078-0432.ccr-24-1779","title":"Complete Remissions of HER2-Positive Trastuzumab-Resistant Xenografts Using a Potent [225Ac]Ac-Labeled Anti-HER2 Antibody–Drug Radioconjugate","year":2024,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Royal University Hospital; Canadian Nuclear Laboratories; University of Saskatchewan; Saskatoon Medical Imaging; Université Laval; Centre hospitalier de l'Université Laval; Hôtel-Dieu de Québec","funders":"Canadian Institutes of Health Research","keywords":"Trastuzumab; Biodistribution; Medicine; Pharmacology; Cancer; Internal medicine; Breast cancer; Chemistry; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001402543,0.0002119339,0.0003063684,0.0001216552,0.0001275502,0.0002140471,0.0001896773,0.0001897015,0.0007184391],"category_scores_gemma":[0.00008090852,0.00008793563,0.000156961,0.0001056746,0.000110059,0.0001592966,0.000101743,0.000461853,0.0001743368],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002891317,"about_ca_system_score_gemma":0.0001748954,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006890043,"about_ca_topic_score_gemma":0.00100773,"domain_scores_codex":[0.99993,0.000007393246,0.000004947748,0.00001344008,0.00002120552,0.00002297228],"domain_scores_gemma":[0.999943,0.000006583071,0.00001374083,0.00001273604,0.000004395483,0.00001954266],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001028016,0.000557868,0.0008854835,0.0000816645,0.00004223221,0.0001590729,0.00005183447,0.0007588865,0.9813968,0.0001643401,0.0005575006,0.01431633],"study_design_scores_gemma":[0.000655998,0.01142681,0.01363708,0.00001089182,0.00009926338,0.001335536,0.0000469129,0.003033068,0.9607827,0.00008730347,0.008872894,0.00001142196],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953811,0.001178725,0.001257344,0.00007838583,0.0000268103,0.00006345619,0.0002325064,0.0001031717,0.001678376],"genre_scores_gemma":[0.9973826,0.0004118193,0.0004316535,0.00003546407,0.000007770002,0.0000232284,0.0003406287,0.00001313394,0.00135372],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007184391,"threshold_uncertainty_score":0.002403438,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3261372075780715,"score_gpt":0.588059894922568,"score_spread":0.2619226873444966,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}