{"id":"W4405374533","doi":"10.1016/j.iotech.2024.100886","title":"2O TILs and PD-L1 early dynamics in the randomized Neo-CheckRay phase II trial evaluating neo-adjuvant immuno-radiation and adenosine pathway blockade for early-stage, high risk ER+/HER2- breast cancer (BC)","year":2024,"lang":"en","type":"article","venue":"Immuno-Oncology Technology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Japanese Respiratory Society; Japan Agency for Medical Research and Development","keywords":"Adenosine; Adjuvant; Blockade; Oncology; Stage (stratigraphy); Medicine; Internal medicine; Breast cancer; Randomized controlled trial; Receptor; Biology; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006900099,0.0004693992,0.0009818691,0.0001827844,0.0002248599,0.0009340041,0.0004042047,0.000752826,0.005655898],"category_scores_gemma":[0.0008650804,0.0002231639,0.0006993776,0.0001533327,0.0003604362,0.0005071435,0.0003343398,0.001765339,0.0005595786],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006192671,"about_ca_system_score_gemma":0.0005897122,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005783235,"about_ca_topic_score_gemma":0.001476721,"domain_scores_codex":[0.9997825,0.0000919526,0.00001028395,0.0000476069,0.00002155965,0.00004618485],"domain_scores_gemma":[0.9996113,0.0000872918,0.00008484835,0.00003156727,0.00002735418,0.0001576504],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8995577,0.009143846,0.007157859,0.0004269327,0.000693323,0.00004490071,0.00007636149,0.00100655,0.009483979,0.0002623056,0.003319177,0.06882714],"study_design_scores_gemma":[0.6445383,0.3024023,0.03605192,0.0001338287,0.001343143,0.000189514,0.0001063707,0.003111216,0.004641319,0.001021989,0.006424352,0.00003571014],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937657,0.002002634,0.0002511731,0.000553384,0.0001596014,0.0005272433,0.0007420071,0.00006708909,0.001931123],"genre_scores_gemma":[0.9929863,0.0004798821,0.0005673871,0.0007558672,0.0000951246,0.000760279,0.001405545,0.00001614893,0.002933393],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005655898,"threshold_uncertainty_score":0.01892084,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01471683082262123,"score_gpt":0.3441883121831741,"score_spread":0.3294714813605529,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}