{"id":"W4405375248","doi":"10.1038/s41587-024-02466-y","title":"A general system for targeting MHC class II–antigen complex via a single adaptable loop","year":2024,"lang":"en","type":"article","venue":"Nature Biotechnology","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"Stanford Maternal and Child Health Research Institute; National Institute of General Medical Sciences; National Heart, Lung, and Blood Institute; Stanford University; Canada Research Chairs; U.S. Department of Health and Human Services; National Institutes of Health; National Science Foundation; National Institute on Drug Abuse; Stanford Bio-X; National Institute of Allergy and Infectious Diseases; Howard Hughes Medical Institute; American Cancer Society","keywords":"T-cell receptor; Antigen; Major histocompatibility complex; Biology; Peptide; In silico; Cell biology; Computational biology; Chemistry; T cell; Immunology; Biochemistry; Immune system; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003979302,0.0005616573,0.0005239734,0.0002425532,0.0003206203,0.0005424041,0.001112736,0.0007844734,0.002129473],"category_scores_gemma":[0.000442513,0.0003032043,0.0004329122,0.0002292677,0.0006247995,0.0009798034,0.0007410206,0.001360312,0.001176065],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005028337,"about_ca_system_score_gemma":0.0003149471,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001719769,"about_ca_topic_score_gemma":0.0001693118,"domain_scores_codex":[0.9997309,0.00003739773,0.00001734636,0.0001179448,0.00005246631,0.00004389313],"domain_scores_gemma":[0.9998129,0.00003644383,0.00003358586,0.00005964907,0.00001897147,0.00003852042],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001078805,0.00003207262,0.00006946488,0.00008625528,0.00001001583,0.00003858646,0.0000340066,0.0009455896,0.9864926,0.005658788,0.000272608,0.006252261],"study_design_scores_gemma":[0.00008555319,0.0006361883,0.0002614198,0.00001214774,0.00004080364,0.0001875118,0.000011626,0.01894886,0.9603561,0.003175754,0.01623425,0.00004993258],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.3985145,0.001292143,0.5860404,0.0009111951,0.0006566754,0.0004557131,0.000423145,0.005297036,0.006409164],"genre_scores_gemma":[0.8519956,0.0007883296,0.1342484,0.0005854375,0.0001175025,0.0007723141,0.0003537885,0.0002759963,0.01086268],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.002129473,"threshold_uncertainty_score":0.007123768,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01265417314292937,"score_gpt":0.2466852385131172,"score_spread":0.2340310653701879,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}