{"id":"W4405393673","doi":"10.1093/rap/rkae140","title":"The pattern of anti-IL-6 versus non-anti-IL-6 biologic disease modifying anti-rheumatic drugs use in patients with rheumatoid arthritis in Wales, UK: a real-world study using electronic health records","year":2024,"lang":"en","type":"article","venue":"Rheumatology Advances in Practice","topic":"Rheumatoid Arthritis Research and Therapies","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Regeneron Pharmaceuticals; Biogen; Gilead Sciences; Sanofi; Chugai Pharmaceutical; Amgen; Pfizer; Health and Care Research Wales; Eli Lilly and Company","keywords":"Medicine; Discontinuation; Internal medicine; Tocilizumab; Rheumatoid arthritis; Rheumatology; TNF inhibitor; Retrospective cohort study; Population; Etanercept; Cohort","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002405407,0.0005405264,0.001576857,0.001093451,0.0002870522,0.0001405834,0.0003991103,0.0001277486,0.00002391625],"category_scores_gemma":[0.001814479,0.0004123938,0.0001145834,0.001821121,0.0005201115,0.001796123,0.0001857822,0.00144302,0.00001675332],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006054535,"about_ca_system_score_gemma":0.001281537,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.008765125,"about_ca_topic_score_gemma":0.02138435,"domain_scores_codex":[0.993531,0.001478434,0.001775464,0.0009964493,0.0006819162,0.001536754],"domain_scores_gemma":[0.9938886,0.004160725,0.0006977079,0.0008230709,0.0002048344,0.0002250398],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003328722,0.001563291,0.9424106,0.0004135659,0.000271643,0.0002703209,0.00227629,0.0003528745,0.000009725635,0.0004430431,0.0000169795,0.04864298],"study_design_scores_gemma":[0.04213814,0.005493938,0.8973996,0.02395657,0.00005427733,0.0003334765,0.01673318,0.008679599,0.00005528195,0.0007792575,0.002998895,0.001377764],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9368793,0.05936346,0.0001288354,0.0006338939,0.0005828808,0.002232876,0.00004312933,0.00007814732,0.00005751893],"genre_scores_gemma":[0.6982803,0.3011862,0.0002424616,0.00003477374,0.000004882011,0.0001436892,0.00004468903,0.00005708653,0.000005913285],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2418227,"threshold_uncertainty_score":0.9998328,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01817873085981289,"score_gpt":0.3369193003951443,"score_spread":0.3187405695353315,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}