{"id":"W4405394420","doi":"10.1016/j.celrep.2024.115071","title":"Temperature perception by ER UPR promotes preventive innate immunity and longevity","year":2024,"lang":"en","type":"article","venue":"Cell Reports","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ministry of Agriculture","funders":"Fundamental Research Funds for the Central Universities; University of Science and Technology of China; National Natural Science Foundation of China","keywords":"Longevity; Innate immune system; Immunity; Biology; Perception; Immunology; Medicine; Gerontology; Immune system; Neuroscience","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001586529,0.0002747115,0.0002974286,0.0001798446,0.0001508806,0.0003839017,0.0001360593,0.0002679972,0.001180054],"category_scores_gemma":[0.00008877167,0.0001215814,0.0003674054,0.00007945215,0.0002174884,0.0003381035,0.0003682028,0.0004578369,0.000280071],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002556279,"about_ca_system_score_gemma":0.0001659036,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002209859,"about_ca_topic_score_gemma":0.0003968902,"domain_scores_codex":[0.999881,0.0000197606,0.0000097056,0.00003736873,0.00002084899,0.00003126398],"domain_scores_gemma":[0.9999142,0.000005710292,0.00003247434,0.00001123784,0.00001537635,0.00002103272],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002091353,0.00001647442,0.0005715706,0.0000478677,0.000007334892,0.00005181965,0.00001738068,0.00004131675,0.9975868,0.0001337105,0.00006066084,0.001255739],"study_design_scores_gemma":[0.00002621347,0.0005468122,0.07206259,0.00003476769,0.00006561943,0.0004140044,0.0001619759,0.001561195,0.9184001,0.0005459811,0.006158982,0.00002185774],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9894292,0.005002147,0.002999256,0.0002233552,0.0000903438,0.00001527901,0.0004248391,0.0001391189,0.001676516],"genre_scores_gemma":[0.9958603,0.001139755,0.001014196,0.00007729508,0.00002022078,0.00001549992,0.0002450331,0.0000170514,0.001610695],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001180054,"threshold_uncertainty_score":0.003947675,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004499951043001208,"score_gpt":0.2199414413675947,"score_spread":0.2154414903245935,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}